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文献和实验Induction of Tumor Cell Apoptosis by TRAIL Gene Therapy
Members of the tumor necrosis factor (TNF) superfamily influence a variety of immunological functions, including cellular activation, proliferation, and death, upon interaction with a corresponding superfamily of receptors
Among cytokine families, the tumor necrosis factor (TNF) superfamily stands out as the one that contains several members with cytotoxic activity (1 –3 ). The best characterized is the prototypic member TNF-α, which is cytotoxic to a range
Biochemical Analysis of the Native TRAIL Death-Inducing Signaling Complex
The extrinsic apoptosis pathway is activated when certain members of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) are oligomerized by their cognate ligands that are members of the TNF superfamily (TNFSF). The apoptosis
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