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文献和实验Cloning and Expression of Human Inducible Nitric Oxide Synthase
Much of the excitement over nitric oxide (NO) is owing to its diverse physiologic and pathophysiologic functions. Induced NO production has been shown to have both beneficial and detrimental consequences. The inducible or high-output
Immunochemical Detection of Nitric Oxide Synthase in Human Tissue
To date three distinct isoforms of nitric oxide synthase (NOS) have been identified. Two isoforms are considered to be expressed constitutively—neu-ronal NOS (nNOS; type I NOS) and endothelial NOS (eNOS; type III NOS). The third isoform
for neurotransmission and learning, and NOS3 regulates vascular tone and adhesion of circulating cells. Inducible NOS (iNOS or NOS2) is transcriptionally induced by proinflammatory cytokines (such as tumor necrosis factor-α [TNF-α] and interferon-γ [IFN
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