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文献和实验Image Figure 2.12.5 Alignment of Grb2 protein sequences. Alignment of human, mouse, rat, worm, fly, and mosquito Grb2 sequences generated
CADASIL: Molecular Mechanisms and Animal Models
. CADASIL mutations encode amino acid substitutions that increase or decrease the number of cysteines within the extracellular epidermal growth factor (EGF) repeat domain of the NOTCH3 receptor protein. Histological studies of CADASIL patients have shown
of artificial transcription factors were created and used to select in vivo protein-DNA interactions that confer a desired phenotype or molecular function to human cells through the activation of one or more genomic loci. Results and discussion
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