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- 2025年07月11日
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文献和实验The Mouse Model of Collagen-Induced Arthritis
Collagen-induced arthritis (CIA) is an experimental autoimmune disease that can be elicited in susceptible strains of rodents (rat and mouse) and nonhuman primates by immunization with type II collagen (CII), the major constituent protein
Analysis of Arthritic Lesions in the Del1 Mouse: A Model for Osteoarthritis
of Col2a1 transgenes with a short deletion mutation results in production of shortened proα1(II) collagen chains and a phenotype resembling human OA. This chapter describes techniques and practical aspects of preparation and processing of skeletal samples
in the circulation, and their levels are believed to reflect type II collagen synthesis. In this chapter we describe the development of a specific enzyme-linked immunosorbent assay (ELISA) for the measurement of the IIA form of PIINP (PIIANP) in serum based
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