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Anti-CD20-Anti-CD3 IgM format

Bispecific Antibody
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  • 询价
  • BPS Bioscience已认证
  • 美国
  • 100860-1
  • 2025年11月26日
    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      -80°C (dry ice)

    • 保质期

      At least 12 months at -80°C. Avoid freeze/thaw cycles.

    • 英文名

      Anti-CD20-Anti-CD3 IgM format Bispecific Antibody

    • 库存

      1

    • 供应商

      BPS Bioscience Inc.

    • CAS号

      /

    • 规格

      50 µg

    His-tagged Anti-CD20-Anti-CD3 IgM format bispecific antibody is a purified recombinant human bispecific antibody with T cell Engager. This bispecific antibody has been tested for specific activity in the functional reporter assay using NFAT-luc reporter Jurkat cell line (BPS Bioscience #60621) in the presence of CD20-CHO cells (BPS Bioscience #79624-H).  The IgM Fc region is pentameric, so there are 5 copies of the anti-CD20 antibodies and J chain has anti-CD3 antibody. 

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    图标文献和实验
    该产品被引用文献
    This product is for research use only.  It is not suitable for human diagnostic or therapeutic use. The anti-CD20-anti-CD3 IgM format bispecific antibody can be used for studying CD20+ cancer cell-mediated T cell activation, using either primary T cell
    相关实验
    • 【翻译】Development trends for monoclonal antibody cancer therapeutics

      ). However, since 2000, humanized and human mAbs have been entering clinical study at approximately the same rate (4.3 versus 4.5 mAbs per year, respectively). Figure 1 | Categories of monoclonal antibody cancer therapeutics entering clinical study during 1980–1989

    • Intracellular Cytokine Staining Protocol

      -gamma, TNF-alpha, IL-2, and IL-4, a combination of PMA (a PKC activator) and Ionomycin (a calcium ionophore) or anti-CD3 antibodies are used. To induce IL-6, IL-10 or TNF-alpha production by monocytes, stimulation of PBMC's with LPS is used.Note: Optimal

    • Intracellular Cytokine Staining Protocol

      to produce IFN-gamma, TNF-alpha, IL-2, and IL-4, a combination of PMA (a PKC activator) and Ionomycin (a calcium ionophore) or anti-CD3 antibodies are used. To induce IL-6, IL-10 or TNF-alpha production by monocytes, stimulation of PBMC's with LPS is used

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    Anti-CD20-Anti-CD3 IgM format Bispecific Antibody
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