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- 2025年12月05日
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-20°C, sealed storage, away from moisture
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货期：1-2天
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10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥875.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥500.0 |
| 规格： | 5 mg | 产品价格： | ￥1150.0 |
| 规格： | 10 mg | 产品价格： | ￥1850.0 |
| 规格： | 25 mg | 产品价格： | ￥3700.0 |
| 规格： | 50 mg | 产品价格： | ￥5920.0 |
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S1R agonist 2 hydrochloride
MCE 国际站：S1R agonist 2 hydrochloride
产品活性：S1R agonist 2 (Compound 8b) hydrochloride 是一种选择性 S1R 激动剂，对 S1R 和 S2R 的 Ki 分别为 1.1 nM 和 88 nM。S1R agonist 2 hydrochloride 对 ROS 和 NMDA 诱导的神经毒性具有神经保护作用。
研究领域：Neuronal Signaling
作用靶点：Sigma Receptor
In Vitro: S1R agonist 2 (Compound 8b; 0.1-5 μM) hydrochloride significantly increases the nerve growth factor (NGF) induced neurite outgrowth at all the tested concentrations in a dose-dependent manner.
S1R agonist 2 (24 h) hydrochloride significantly prevents cell damage induced by Rotenone (HY-B1756) when tested at the concentration of 1 μM in SHSY5Y cells.
S1R agonist 2 (0.1-5 μM; 24 h) hydrochloride demonstrates a neuroprotective effect against NMDA stimuli in SHSY5Y cells.
S1R agonist 2 (0-10 μM; 24-72 h) hydrochloride shows no cytotoxicity against A549, LoVo and Panc-1 cells.
In Vivo: S1R agonist 2 (Compound 8b; 0.1-50 μM; 120 h) hydrochloride does not induce embryo death (100% of embryos alive) at 10 μM, but induces the death of all zebrafish embryo at the highest dose tested (50 μM).
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文献和实验Measurement of Agonist-Stimulated [35S]GTPS Binding to Cell Membranes
This chapter describes a functional assay which measures the increase in guanine nucleotide exchange at G-proteins in cell membranes, resulting from agonist binding to G-protein-coupled receptors (GPCRs), by monitoring the binding of [35 S
preparations, GTP can be substituted by 35 S-labeled guanosine 5′-O -(3-thio)triphosphate ([35 S]GTγS) and on agonist stimulation a stable [35 S]GTPγS-Gα complex will form and accumulate. Separation of 35 S-bound GTPγS-Gα complexes from free [35 S]GTPγS allows
due to its potential to artificially increase endurance. Consequently, sports drug testing laboratories need to establish detection methods enabling the identification of the intact substance and/or its metabolite(s) that unambiguously prove
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