NMDA receptor antagonist 7

Chemokine Receptor Antagonist Development

This chapter describes assays that focus on the characterization of compounds identified in high-�throughput screening campaigns, and the subsequent medicinal chemistry programs. They cover methods to determine potency

Engineering the NMDA Receptor Channel Lining

Neurotransmitter-gated channels, such as the NMDA receptor, are oligomeric membrane proteins assembled from multiple homologous subunits organized around a central ion-conducting pore (1 ,2 ). A major effort is directed toward understanding

High-Throughput Functional Detection of NMDA Receptor Activity

target protein. The heterologous expression of cloned receptor proteins in defined cell lines provides the specificity of the interaction.