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文献和实验Chemokine Receptor Antagonist Development
This chapter describes assays that focus on the characterization of compounds identified in high-�throughput screening campaigns, and the subsequent medicinal chemistry programs. They cover methods to determine potency
Engineering the NMDA Receptor Channel Lining
Neurotransmitter-gated channels, such as the NMDA receptor, are oligomeric membrane proteins assembled from multiple homologous subunits organized around a central ion-conducting pore (1 ,2 ). A major effort is directed toward understanding
High-Throughput Functional Detection of NMDA Receptor Activity
target protein. The heterologous expression of cloned receptor proteins in defined cell lines provides the specificity of the interaction.
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