BioLegend 938102 Purified anti

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BioLegend 938102 Purified anti-p63 (TA)
产品简介：
产品品牌：BioLegend
产品货号：938102
产品名称：BioLegend 938102 Purified anti-p63 (TA)
产品规格：100 µg

产品说明：
Clone   TAp63-4.1 (See other available formats)
Regulatory Status   RUO
Other Names
TP63,Tumor Protein P63, P63, Transformation-Related Protein 63, Tumor Protein 63, P73L, Tumor Chronic Ulcerative Stomatitis Protein, Keratinocyte Transcription Factor KET, Protein P73-Like, Tumor Protein P53-Competing Protein
Isotype   Mouse IgG2a, κ

描述
p63是p53转录因子家族的成员。TP63基因编码两种主要的亚型，p63（TA）和p63（ΔN），它们是通过选择性启动子使用从选择性起始位点产生的。p63（TA）能够诱导p53依赖性启动子的表达，包括那些控制编码凋亡反应蛋白Noxa和Puma的基因表达的启动子。它还被证明通过诱导编码Sirt1、AMPKα2和LKB1蛋白的基因来响应代谢应激，在能量代谢中发挥作用。虽然p63（ΔN）缺乏TA结构域，但它保留了反式激活功能，并可以诱导一些启动子的表达；它还可以通过形成螯合TAp63并使其失活的异源四聚体来发挥显性负性功能，从而促进肿瘤发生。
p63 is a member of the p53 family of transcription factors. The TP63 gene encodes two major isoforms, p63 (TA) and p63 (ΔN) that are produced from alternative start sites through alternative promoter usage. p63 (TA) is able to induce expression from p53-dependent promoters, including those that control the expression of genes encoding the apoptotic response proteins Noxa and Puma. It has also been shown to play a role in energy metabolism by inducing genes encoding Sirt1, AMPKα2, and LKB1 proteins in response to metabolic stress. While p63 (ΔN) lacks the TA domain, it retains transactivation function and can induce expression from some promoters; it can also exert dominant-negative function by forming heterotetramers that sequester TAp63 and render it inactive, thereby promoting tumorigenesis.

Product Details
Isotype Control   Purified Mouse IgG2a, κ Isotype Ctrl
Verified Reactivity    Human
Antibody Type    Monoclonal
Host Species    Mouse
Immunogen
Full-length recombinant human p63 (TA) protein

Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide

Preparation
The antibody was purified by affinity chromatography.
Concentration    0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application    WB - Quality tested
ICC, IP - Verified

Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 1 µg/mL. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg/mL is recommended. For immunoprecipitation, the suggested use of this reagent is 2.5 µg/test. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details
Structure
p63 (TA) is a 680 amino acid protein with a predicted molecular weight of 76 kD.
Distribution    Nucleus
Function    Transcription factor

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