产品说明: Clone Poly19055 (See other available formats) Regulatory Status RUO Other Names Keratin, type II cytoskeletal 5, CK-5, 58 kda cytokeratin, type-II keratin Kb5, epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types, keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types), krt5 Isotype Rabbit Polyclonal
描述 角蛋白5是II型(碱性或中性)细胞角蛋白家族的成员。一般来说,II型角蛋白是在单层和分层上皮组织分化过程中共同表达的异聚结构蛋白。角蛋白5与角蛋白14一起在表皮的基底层中特异性表达。 Keratin 5 is a member of the type II (basic or neutral) cytokeratin family. Type II keratins, in general, are heteropolymeric structural proteins coexpressed during differentiation of simple and stratified epithelial tissues. Keratin 5 is specifically expressed in the basal layer of the epidermis along with Keratin 14.
Product Details Isotype Control Purified Rabbit Polyclonal Isotype Ctrl Verified Reactivity Human, Mouse, Rat Reported Reactivity Dog, Non-Human Primate Antibody Type Polyclonal Host Species Rabbit Immunogen This monospecific polyclonal antibody was raised against a peptide sequence derived from the C-terminus of the mouse keratin 5 protein.
Preparation The antibody was purified by affinity chromatography.
Concentration 0.5 mg/ml Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C. Application IHC-P - Quality tested WB, ICC - Verified
Recommended Usage Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemisty, a concentration range of 0.2 - 5.0 μg/ml is suggested. For Western blotting, a concentration range of 0.5 - 1.0 μg/ml is suggested. For immunocytochemistry, a concentration range of 0.5 - 1.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details Structure Keratin 5 is a 62 kD protein. Distribution Cytoskeleton, extracellular, and nucleus. Function Keratin 5 mutations have been associated with a complex of diseases termed epidermolysis bullosa simplex.
Biology Area Cell Biology, Cell Motility/Cytoskeleton/Structure, Neuroscience, Neuroscience Cell Markers Molecular Family Intermediate Filaments
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