产品说明: Clone Poly18339 (See other available formats) Regulatory Status RUO Other Names Keratin, type I cytoskeletal 15, CK-15, cytokeratin-15, keratin-15, beta, keratin-15, basic keratin-15, K15, cytokeratin 15, cytokeratin15 Isotype Chicken IgY
描述 角蛋白是负责上皮细胞结构完整性的中间丝蛋白,分为细胞角蛋白和毛角蛋白。角蛋白15是I型细胞角蛋白家族的成员。大多数I型细胞角蛋白由酸性蛋白质组成,这些蛋白质排列成成对的异型角蛋白链。角蛋白15与恶性汗管瘤和变形型基底细胞癌等疾病有关。 Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 15 is a member of the type I cytokeratin family. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chain. Keratin 15 has been associated with diseases such as malignant syringoma and morpheaform basal cell carcinoma.
Product Details Verified Reactivity Human, Mouse Reported Reactivity Non-Human Primate Antibody Type Polyclonal Host Species Chicken Immunogen This antibody was raised against a peptide sequence derived from the C-terminus of the human keratin 15 protein, CDGQVVSSHKREI.
Preparation The antibody was purified by affinity chromatography. Concentration 0.5 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C. Application IHC-P - Quality tested WB - Verified
Recommended Usage Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10 μg/ml is suggested. For Western blotting, a concentration range of 1.0 - 10 μg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details Structure Keratin 15 is a 456 amino acid protein with a molecular mass of 49 kD.
Distribution Tissue distribution: skin. Cellular distribution: extracellular, nucleus, and cytoskeleton.
Function Keratin 15 is responsible for maintaining the structural integrity of mammalian epithelial cells.
Biology Area Cell Biology, Cell Motility/Cytoskeleton/Structure, Neuroscience, Neuroscience Cell Markers Molecular Family Intermediate Filaments
以下是 BioLegend 品牌部分产品,如需其他产品请联系本公司销售。 BioLegend 102049 Brilliant Violet 711™ anti-mouse CD25 PC61 50 ug BioLegend 102051 Brilliant Violet 785™ anti-mouse CD25 PC61 50 ug BioLegend 102058 Ultra-LEAF™ Purified anti-mouse CD25 PC61 5 mg BioLegend 102059 Ultra-LEAF™ Purified anti-mouse CD25 PC61 25 mg BioLegend 102063 KIRAVIA Blue 520™ anti-mouse CD25 PC61 25 ug BioLegend 102071 PE/Fire™ 640 anti-mouse CD25 PC61 25 ug BioLegend 102075 APC/Fire™ 810 anti-mouse CD25 PC61 25 ug BioLegend 102101 Purified anti-mouse CD28 37.51 50 ug BioLegend 102102 Purified anti-mouse CD28 37.51 500 ug BioLegend 102103 Biotin anti-mouse CD28 37.51 50 ug BioLegend 102104 Biotin anti-mouse CD28 37.51 500 ug BioLegend 102105 PE anti-mouse CD28 37.51 50 ug BioLegend 102106 PE anti-mouse CD28 37.51 200 ug BioLegend 102109 APC anti-mouse CD28 37.51 25 ug BioLegend 102110 APC anti-mouse CD28 37.51 100 ug BioLegend 102114 PerCP/Cyanine5.5 anti-mouse CD28 37.51 100 ug BioLegend 102115 Ultra-LEAF™ Purified anti-mouse CD28 37.51 100 ug BioLegend 102122 Ultra-LEAF™ Purified anti-mouse CD28 37.51 25 mg BioLegend 102125 PE/Cyanine7 anti-mouse CD28 37.51 25 ug BioLegend 102126 PE/Cyanine7 anti-mouse CD28 37.51 100 ug BioLegend 102127 Brilliant Violet 421™ anti-mouse CD28 37.51 50 ug BioLegend 102136 KIRAVIA Blue 520™ anti-mouse CD28 37.51 100 ug