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99
- 英文名：
Purified anti-TMEM119 (Extracellular)
- 供应商：
北京云肽生物科技有限公司
BioLegend 853302 Purified anti-TMEM119 (Extracellular)
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
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BioLegend 853302 Purified anti-TMEM119 (Extracellular)
产品简介：
产品品牌：BioLegend
产品货号：853302
产品名称：BioLegend 853302 Purified anti-TMEM119 (Extracellular)
产品规格： 100 µg
产品说明：
Clone A16075D (See other available formats)
Regulatory Status RUO
Other Names Transmembrane protein 119
Isotype Mouse IgG2b, κ
描述
小胶质细胞是中枢神经系统的固有实质髓细胞，在发育、稳态、疾病和损伤中发挥着重要作用。TMEM119是一种跨膜蛋白，在小鼠和人类中枢神经系统中都被鉴定为小胶质细胞特异性标记。此外，TMEM119免疫反应性仅在神经退行性疾病大脑中具有分支和变形虫形态的Iba1（+）CD68（+）小胶质细胞亚群上检测到。TMEM119在骨形成和正常骨矿化中也起着重要作用。它促进成肌细胞分化为成骨细胞。并可诱导成肌细胞向成骨细胞分化。TMEM119对于正常精子发生和晚期睾丸分化也是必不可少的。
Microglia are the resident parenchymal myeloid cells of the CNS, and play an important role in development, homeostasis, disease, and injury. TMEM119 is a transmembrane protein and was identified as a microglia-specific marker in both mouse and human CNS. Moreover, TMEM119 immunoreactivity has been exclusively detected on a subset of Iba1(+) CD68(+) microglia with ramified and amoeboid morphologies in the brains of neurodegenerative diseases. TMEM119 also plays an important role in bone formation and normal bone mineralization. It promotes the differentiation of myoblasts into osteoblasts. and it may induce the commitment and differentiation of myoblasts into osteoblasts. TMEM119 is also essential for normal spermatogenesis and late testicular differentiation.
Product Details
Isotype Control Purified Mouse IgG2b, κ Isotype Ctrl
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen
Recombinant human TMEM119 protein (extracellular domain)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration 0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application FC - Quality tested
WB, ICC, IHC-P - Verified
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.6 - 5.0 µg/mL. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per mL. For immunocytochemistry, a concentration range of 2.0 - 5.0 µg/mL is suggested. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details
Structure
TMEM119 is an 283 amino acid protein with a molecular mass of 30 kD.
Distribution
Tissue distribution: TMEM119 is expressed in the brain, bone, and lymphoid tissues.
Cellular distribution: Membrane and endoplasmic reticulum.
Function
TMEM119 is an important microglia marker and is implicated in neurodegenerative diseases.
Interaction TMEM119 interacts with SMAD1, SMAD5 and RUNX2.
Biology Area Cell Biology, Neuroscience, Neuroscience Cell Markers
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BioLegend 853302 Purified anti-TMEM119 (Extracellular)
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