BioLegend 822501 Purified anti

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BioLegend 822501 Purified anti-MAP2
产品简介：
产品品牌：BioLegend
产品货号：822501
产品名称：BioLegend 822501 Purified anti-MAP2
产品规格：50 µL

产品说明：
Clone   Poly28225 (See other available formats)
Regulatory Status   RUO
Other Names    Microtubule-associated protein 2, MAP-2
Previously    Covance Catalog# PCK-554P
Isotype   Chicken IgY

描述
微管是在大多数真核生物细胞中发现的直径为25nm的蛋白质棒。它们由一个α亚基和一个β微管蛋白亚基组成的二聚亚基聚合而成。微管与一个称为微管相关蛋白（MAP）的蛋白质家族相关，该家族包括蛋白质τ（tau）和一组称为MAP1、MAP2、MAP3、MAP4和MAP5的蛋白质。MAP2由两个约280kD的表观分子量带组成，称为MAP2a和MAP2b。第三种较低分子量的形式，通常称为MAP2c，对应于SDS-PAGE凝胶上一对以约70 kD运行的蛋白质带。所有这些MAP2形式都通过替代转录来源于单个基因，并且都共享一个C末端序列，该序列包括三个或四个微管结合肽序列，这些序列与相关微管结合蛋白τ（tau）中发现的序列非常相似。MAP2亚型仅在神经元细胞中表达，特别是在这些细胞的胞周和树突中表达。因此，MAP2抗体是神经元细胞、其胞周和神经元树突上的优秀标志物。相反，τ（tau）主要存在于神经元轴突中。
Microtubules are 25nm diameter protein rods found in most kinds of eukaryote cells. They are polymerized from a dimeric subunit made of one α subunit and one β tubulin subunit. Microtubules are associated with a family of proteins called microtubule associated proteins (MAPs), which includes the protein τ (tau) and a group of proteins referred to as MAP1, MAP2, MAP3, MAP4 and MAP5. MAP2 is made up of two ~280kD apparent molecular weight bands referred to as MAP2a and MAP2b. A third lower molecular weight form, usually called MAP2c, corresponds to a pair of protein bands running at ~70 kD on SDS-PAGE gels. All these MAP2 forms are derived from a single gene by alternative transcription, and all share a C-terminal sequence which includes either three or four microtubule binding peptide sequences, which are very similar to those found in the related microtubule binding protein τ (tau). MAP2 isoforms are expressed only in neuronal cells and specifically in the perikarya and dendrites of these cells. Antibodies to MAP2 are therefore excellent markers on neuronal cells, their perikarya and neuronal dendrites. In contrast τ (tau) is found predominantly in neuronal axons.

Product Details
Verified Reactivity   Human, Rat, Mouse, Bovine
Antibody Type   Polyclonal
Host Species   Chicken
Immunogen
This antibody was made against MAP2 in chickens.

Preparation
The antibody was purified by affinity chromatography.

Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application   IHC-P - Quality tested
WB

Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining.

Antigen Details
Cell Type   Neural Stem Cells
Biology Area
Cell Biology, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family   Microtubules

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