BioLegend 800706 Biotin (azide

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BioLegend 800706 Biotin (azide-free) anti-β-Amyloid, 17-24
产品简介：
产品品牌：BioLegend
产品货号：800706
产品名称：BioLegend 800706 Biotin (azide-free) anti-β-Amyloid, 17-24
产品规格：1 mL

产品说明：
Clone   4G8 (See other available formats)
Regulatory Status   RUO
Workshop   HCDM listed
Other Names
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein

Previously    Signet Catalog# 9240-02
Signet Catalog# 9240-05
Signet Catalog# 9240-10
Covance Catalog# SIG-39240
Isotype    Mouse IgG2b, κ

描述
阿尔茨海默病的特征是聚集的Aβ肽在老年斑块和血管沉积物中积聚。Aβ肽来源于淀粉样蛋白前体蛋白（APP），通过β-分泌酶和γ-分泌酶对APP的顺序蛋白水解切割产生不同的Aβ种类。β可以聚集形成可溶性寡聚物和不溶性原纤维或无定形组装体。某些形式的聚集肽对神经元是有毒的。
Alzheimer’s disease is characterized by the accumulation of aggregated Aβ peptides in senile plaques and vascular deposits. Aβ peptides are derived from amyloid precursor proteins (APP) through sequential proteolytic cleavage of APP by β-secretases and γ-secretases generating diverse Aβ species. Aβ can aggregate to form soluble oligomeric species and insoluble fibrillar or amorphous assemblies. Some forms of the aggregated peptides are toxic to neurons.

Product Details
Verified Reactivity   Human, Mouse
Antibody Type   Monoclonal
Host Species   Mouse
Formulation
Phosphate-buffered solution (no preservatives or carrier proteins).

Preparation
The antibody was purified by affinity chromatography.
Concentration   1 mg/ml

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application    IHC-P - Quality tested
Direct ELISA - Verified

Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 2.0 µg/ml is suggested. For Direct ELISA applications, a concentration range of 0.5 - 2.0 µg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details
Structure
Amyloid precursor protein is a 770 amino acid protein with a molecular mass of ~100 kD. According to the UniProtKB database, APP (ID# P05067) has 11 isoforms (34 to ~90 kD) and the 770 form has been designated as the canonical form. Isoform APP695 is the predominant form expressed in neuronal tissue. Isoforms APP751 and APP770 are widely expressed in non-neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Aβ denotes peptides of 36-43 amino acids generated from cleavage of APP by secretases. Aβ has an apparent molecular mass of about 4 kD.

Distribution
Tissue distribution: Primarily nervous system, but also adipose tissue, intestine, and muscle.
Cellular distribution: Cytosol, endosomes, nucleus, plasma membrane, extracellular, and golgi apparatus.

Function
The normal function of Aβ is not well understood. Several potential physiological roles have been proposed, including: activation of kinase enzymes; protection against oxidative stress; regulation of cholesterol transport; transcription factor, and as an anti-microbial agent.

Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family    APP/β-Amyloid

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