BioLegend 805404 Biotin (azide

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BioLegend 805404 Biotin (azide-free) anti-β-Amyloid, 1-40
产品简介：
产品品牌：BioLegend
产品货号：805404
产品名称：BioLegend 805404 Biotin (azide-free) anti-β-Amyloid, 1-40
产品规格： 200 µL

产品说明：
Clone   11A50-B10 (See other available formats)
Regulatory Status   RUO
Other Names
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein

Previously     Signet Catalog# 9141-02
Signet Catalog# 9141-05
Signet Catalog# 9141-10
Covance Catalog# SIG-39141
Isotype   Mouse IgG1, κ

描述
淀粉样β（Aβ或淀粉样β）是指长度为36-43个氨基酸的肽，作为阿尔茨海默病患者大脑中淀粉样斑块的主要成分，与阿尔茨海默病密切相关。这些肽来自淀粉样蛋白前体蛋白（APP），该蛋白被某些酶切割产生Aβ。Aβ分子可以聚集形成低聚物（称为“种子”），据信这种低聚物能够诱导其他Aβ分子也采取错误折叠的低聚物形式，从而导致类似朊病毒感染的连锁反应。种子或由此产生的淀粉样蛋白斑块对神经细胞具有毒性。另一种与阿尔茨海默病有关的蛋白质，tau蛋白，也会形成这种朊病毒样的错误折叠低聚物，有一些证据表明，错误折叠的Aβ会导致tau错误折叠。
Amyloid beta (Aβ or Amyloid beta) denotes peptides of 36-43 amino acids in length that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is cut by certain enzymes to yield Aβ. Aβ molecules can aggregate to form oligomers (known as "seeds") which are believed to be able to induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The seeds or the resulting amyloid plaques are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.

Product Details
Verified Reactivity   Human
Antibody Type   Monoclonal
Host Species   Mouse
Formulation
Phosphate-buffered solution; no preservatives or carrier proteins.

Preparation
The antibody was purified by affinity chromatography.
Concentration   0.5 mg/ml

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application   ELISA, WB, IHC, IP

Recommended Usage
Each lot of this antibody is quality control tested by ELISA assay.

The optimal working dilution should be determined for each specific assay condition.

Antigen Details
Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family   APP/β-Amyloid

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