Sigma货号MAB5374抗-亨廷顿蛋白抗体(克隆mEM4

Inhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6/2 mouse model of Huntington's disease. Giampa, C; Laurenti, D; Anzilotti, S; Bernardi, G; Menniti, FS; Fusco, FR Testing null Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity. Yanchun Pan et al. Scientific reports, 6, 31022-31022 (2016-08-16) Although epigenetic abnormalities have been described in Huntington's disease (HD), the causal epigenetic mechanisms driving neurodegeneration in HD cortex and striatum remain undefined. Using an epigenetic pathway-targeted drug screen, we report that inhibitors of DNA methyltransferases (DNMTs), decitabine and FdCyd An engineered viral protease exhibiting substrate specificity for a polyglutamine stretch prevents polyglutamine-induced neuronal cell death. Sellamuthu, S; Shin, BH; Han, HE; Park, SM; Oh, HJ; Rho, SH; Lee, YJ; Park, WJ Testing null Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. Tomomi Imamura et al. Scientific reports, 6, 33861-33861 (2016-09-23) We identified drug seeds for treating Huntington's disease (HD) by combining in vitro single molecule fluorescence spectroscopy, in silico molecular docking simulations, and in vivo fly and mouse HD models to screen for inhibitors of abnormal interactions between mutant Htt Snake Venom Disintegrin Inhibits the Activation of Toll-Like Receptors and Alleviates Sepsis through Integrin alphaVbeta3 Blockade. Chun-Chieh Hsu et al. Scientific reports, 6, 23387-23387 (2016-03-19) Bacterial infection-induced sepsis is the leading cause of septic inflammatory disease. Rhodostomin (Rn), a snake venom disintegrin, was previously reported to interact with the αVβ3 integrin and the TLR4 on phagocyte in attenuating LPS-induced endotoxemia. In this report, we further