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- 英文名：
BioLegend 669601 Purified anti-METTL14
- 供应商：
北京云肽生物科技有限公司
BioLegend 669601 Purified anti-METTL14
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
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BioLegend 669601 Purified anti-METTL14
产品简介：
产品品牌：BioLegend
产品货号：669601
产品名称：BioLegend 669601 Purified anti-METTL14
产品规格：25 µg
产品说明：
Clone W18219A (See other available formats)
Regulatory Status RUO
Other Names
Methyltransferase Like 14, N6-Adenosine-Methyltransferase Non-Catalytic Subunit, HMETTL14, KIAA1627
Isotype Rat IgG2a, κ
描述
METTL14与METTL3形成一种称为m6A甲基转移酶复合物（MTC）的异二聚体，以甲基化真核信使核糖核酸N6位的腺苷残基。MTC诱导的甲基化发生在一些mRNA的5'-[AG]GAC-3'共有位点。在MTC复合物中，METTL14构成识别底物的RNA结合支架。一旦甲基化，信使核糖核酸就会被称为“读者”的不同蛋白质识别，这将影响其稳定性、剪接和/或翻译。
METTL14 forms a heterodimer with METTL3 called the m6A-methyltransferase complex (MTC) to methylate adenosine residues at the N6 position of eukaryotic mRNAs. MTC-induced methylation takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs. In the MTC complex, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate. Once methylated, the mRNAs are recognized by distinct proteins known as “readers” that will affect their stability, splicing, and/or translation.
Product Details
Verified Reactivity Human, Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen
Partial-length recombinant human METTL14 protein between 1-300 a.a.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration 0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application WB - Quality tested
IP - Verified
Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.025 - 1.0 µg per ml. For immunoprecipitation, the suggested use of this reagent is 2.5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes
While this clone is able to immunoprecipitate METTL14 from whole cell extracts, the resulting fraction was not significantly enriched in METTL14; therefore, this clone may not be suitable for detecting transient or low-abundance complexes.
Antigen Details
Structure
METTL14 is a 456 amino acid protein with a molecular weight of 65 kD.
Distribution
Localized to the mitochondria; ubiquitously expressed.
Function Methylation; mRNA splicing; mRNA translation
Interaction METTL3
Biology Area Protein Synthesis
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BioLegend 669601 Purified anti-METTL14
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