- 询价
- BioLegend
- 658706
- BioLegend
- 2025年12月25日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 库存：
99
- 英文名：
Alexa Fluor® 647 anti-Bcl-2
- 供应商：
北京云肽生物科技有限公司
美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
BioLegend 公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 658706 Alexa Fluor® 647 anti-Bcl-2
产品简介：
产品品牌：BioLegend
产品货号：658706
产品名称：BioLegend 658706 Alexa Fluor® 647 anti-Bcl-2
产品规格：100 tests
产品说明：
Clone 100 (See other available formats)
Regulatory Status RUO
Other Names
B-Cell CLL/Lymphoma 2 (Bcl-2), Protein Phosphatase 1, Regulatory Subunit 50
Isotype Mouse IgG1
描述
Bcl-2是一种保守的抗凋亡蛋白，在正常免疫中发挥重要作用。它与其他Bcl-2家族成员形成同源二聚体或异二聚体。这种蛋白质通过控制线粒体融合和分裂来调节细胞凋亡。Bcl-2的磷酸化已显示出增强活性以允许对细胞外生长因子介导的信号作出反应。Bcl-2还受IRES、miR-15a、miR-16-1和RNA-BP核仁素的调节。在滤泡性淋巴瘤和一些弥漫性大B细胞淋巴瘤中经常观察到染色体18q21.3易位和Bcl-2过表达。
Bcl-2 is a conserved anti-apoptotic protein that plays important roles in normal immunity. It forms homodimers or heterodimers with other Bcl-2 family members. This protein regulates apoptosis through controlling mitochondrial fusion and fission. Phosphorylation of Bcl-2 has been shown to enhance activity to allow response to extracellular growth-factor-mediated signals. Bcl-2 is also regulated by IRES, miR-15a, miR-16-1 and RNA-BP nucleolin. Chromosome 18q21.3 translocation and overexpression of Bcl-2 is frequently observed in follicular lymphomas and some diffuse large B-cell lymphomas.
Product Details
Isotype Control
Alexa Fluor® 647 Mouse IgG1, κ Isotype Ctrl (FC)
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen
Synthetic peptide of amino acids 41-54 of human bcl-2 oncoprotein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application ICFC - Quality tested
SB - Reported in the literature, not verified in house
Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
Antigen Details
Structure
Two isoforms, 239 or 205 amino acids in length, with a predicted molecular weight of 26 kD or 22 kD and four ‘BH' domains.
Distribution
Outer mitochondrial membrane, nuclear membrane, endoplasmic reticulum membrane.
Function
Regulates apoptosis through controlling mitochondrial fusion and fission.
Interaction
BAX, BAD, BAK, Bcl-X(L),EI24,APAF1, BBC3, BCL2L1, BNIPL, MRPL41, TP53BP2, FKBP8 BAG1, RAF1, EGLN3, G0S2, and BOP.
Cell Type B cells
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, Chromatin Remodeling/Epigenetics, Immunology, Mitochondrial Function, Neuroscience, Signal Transduction, Transcription Factors, Ubiquitin/Protein Degradation
以下是 BioLegend 品牌部分产品，如需其他产品请联系本公司销售。
BioLegend 501125 Ultra-LEAF™ Purified anti-human IL-6 MQ2-13A5 100 ug
BioLegend 501202 Biotin anti-human IL-6 MQ2-39C3 500 ug
BioLegend 501302 Purified anti-human IL-7 BVD10-40F6 500 ug
BioLegend 501403 PE anti-human IL-10 JES3-9D7 25 tests
BioLegend 501404 PE anti-human IL-10 JES3-9D7 100 tests
BioLegend 501409 APC anti-human IL-10 JES3-9D7 25 tests
BioLegend 501410 APC anti-human IL-10 JES3-9D7 100 tests
BioLegend 501418 PerCP/Cyanine5.5 anti-human IL-10 JES3-9D7 100 tests
BioLegend 501419 PE/Cyanine7 anti-human IL-10 JES3-9D7 25 tests
BioLegend 501420 PE/Cyanine7 anti-human IL-10 JES3-9D7 100 tests
BioLegend 501421 Brilliant Violet 421™ anti-human IL-10 JES3-9D7 25 tests
BioLegend 501422 Brilliant Violet 421™ anti-human IL-10 JES3-9D7 100 tests
BioLegend 501426 PE/Dazzle™ 594 anti-human IL-10 JES3-9D7 100 tests
BioLegend 501427 Ultra-LEAF™ Purified anti-human IL-10 JES3-9D7 100 ug
BioLegend 501502 Biotin anti-human IL-10 JES3-12G8 500 ug
BioLegend 501702 Purified anti-human IL-12/IL-23 p40 C8.3 500 ug
BioLegend 501807 PE anti-human IL-12/IL-23 p40 C11.5 100 tests
BioLegend 501809 APC anti-human IL-12/IL-23 p40 C11.5 25 tests
BioLegend 501816 Alexa Fluor® 488 anti-human IL-12/IL-23 p40 C11.5 100 tests
BioLegend 501820 Pacific Blue™ anti-human IL-12/IL-23 p40 C11.5 100 ug
BioLegend 501902 Purified anti-human IL-13 JES10-5A2 500 ug
BioLegend 501911 PerCP/Cyanine5.5 anti-human IL-13 JES10-5A2 100 tests 
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验的耐光性和良好的荧光量子产量著称。因此很多Alexa Fluor® 染料具有罗丹明核心结构，但是，传统罗丹明的化学结构很难从长波长的荧光染料延伸至远红外区域甚至是更具挑战性的近红外区域，而且生物偶联后其水溶性并不理想。Biotium 科学家发现从绿色到近红外多色荧光的罗丹明染料的新型化学方法。该方法被有效的应用于CF染料的产品中，尤其是远红外CF染料，而且通过这种方法制备的染料不仅水溶性极佳而且耐光性极好。图1. CF系列染料的稳定性，图示为CF633在5min中仍然具有稳定的荧光强度；而AF647
技术原理与方法｜超级色差校正物镜 PLAPON60XOSC 在脑组织四重免疫荧光分析中的应用
种类型的荧光抗体在单个标本中准确展示荧光标记分子的共定位情况。 PLAPON60XOSC 和 UPLSAPO60XO 的性能比较 2. 超级色差校正物镜的应用-脑组织的四重免疫荧光 图 1. 脑组织的四重免疫荧光。 VIAAT 染色（Alexa Fluor405，蓝色）；CB1 染色（Alexa Fluor488，绿色）；VGluT3 染色（Cy3，红色）；DGLα染色（Alexa Fluor647，白色）。 大麻素合成酶 DGLα（白色）和大麻素受体 CB1（绿色）聚集在小鼠
'）2 Fragment（Alexa Fluor® 555 Conjugate）#4413 Anti-Rabbit IgG（H+L）， F（ab'）2 Fragment（Alexa Fluor® 647 Conjugate）#4414 抗小鼠： Anti-Mouse IgG（H+L）， F（ab'）2 Fragment（Alexa Fluor® 488 Conjugate）#4408 Anti-Mouse IgG（H+L）， F（ab'）2 Fragment（Alexa Fluor
技术资料暂无技术资料 索取技术资料
