BioLegend 654101 Purified anti

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BioLegend 654101 Purified anti-TIF1β (KAP-1, TRIM28) Phospho (Ser473)
产品简介：
产品品牌：BioLegend
产品货号：654101
产品名称：BioLegend 654101 Purified anti-TIF1β (KAP-1, TRIM28) Phospho (Ser473)
产品规格：25 µg

产品说明：
Clone  11G10SC (See other available formats)
Regulatory Status  RUO
Other Names   TRIM28 pS473, KAP-1 pS473
Isotype   Mouse IgG1, κ

描述
转录中间因子（TIFs）是一组转录共激活因子和共抑制因子，通过调节染色质结构和转录起始复合物的组装来调节基因表达。TIF1β是染色质相关TIF1亚家族的一员，在许多发育和生理过程中发挥着关键作用。使用敲除小鼠的研究揭示了TIF1β在调节基因组印迹、T细胞活化和T细胞耐受方面的重要功能。
Transcriptional intermediary factors (TIFs) are a group of transcriptional coactivators and corepressors that regulate gene expression by modulating chromatin structure and assembly of transcription initiation complexes. TIF1β is a member of the TIF1 subfamily of chromatin-associated TIFs that play a key role in many developmental and physiological processes. Studies using knockout mice reveal the important function of TIF1β in regulating genomic imprinting, T cell activation, and T cell tolerance.

Product Details
Verified Reactivity  Human
Antibody Type   Monoclonal
Host Species   Mouse
Immunogen   Modified peptide: VKRSRpSGEGEVC.
Formulation
This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.05% sodium azide.
Concentration   0.5 mg/mL

Storage & Handling
Upon receipt, store undiluted between 2°C and 8°C.
Application   WB - Quality tested
ICC - Verified

Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 1.0 µg per mL. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details
Structure
An N-terminal RING-B box coiled coil (RBCC) domain most likely attributes to intermolecular structure, while two characteristic chromatin-targeting domains, a plextrin homology (PH) finger motif and bromodomain, are found in the C-terminus.
Distribution   Nucleus

Function
TIF1β acts as a transcriptional repressor by modulating histone deacetlyation, histone H3 Ly-9 methylation, and recruitment of HP1 proteins.

Interaction
TIF1β was shown to form homo-oligomers in vitro, but does not form hetero-oligomers with TIF1α or TIF1γ.

Biology Area
Cell Biology, Chromatin Remodeling/Epigenetics, Transcription Factors
Molecular Family   Phospho-Proteins

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