产品说明: Clone 11G10SC (See other available formats) Regulatory Status RUO Other Names TRIM28 pS473, KAP-1 pS473 Isotype Mouse IgG1, κ
描述 转录中间因子(TIFs)是一组转录共激活因子和共抑制因子,通过调节染色质结构和转录起始复合物的组装来调节基因表达。TIF1β是染色质相关TIF1亚家族的一员,在许多发育和生理过程中发挥着关键作用。使用敲除小鼠的研究揭示了TIF1β在调节基因组印迹、T细胞活化和T细胞耐受方面的重要功能。 Transcriptional intermediary factors (TIFs) are a group of transcriptional coactivators and corepressors that regulate gene expression by modulating chromatin structure and assembly of transcription initiation complexes. TIF1β is a member of the TIF1 subfamily of chromatin-associated TIFs that play a key role in many developmental and physiological processes. Studies using knockout mice reveal the important function of TIF1β in regulating genomic imprinting, T cell activation, and T cell tolerance.
Product Details Verified Reactivity Human Antibody Type Monoclonal Host Species Mouse Immunogen Modified peptide: VKRSRpSGEGEVC. Formulation This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.05% sodium azide. Concentration 0.5 mg/mL
Storage & Handling Upon receipt, store undiluted between 2°C and 8°C. Application WB - Quality tested ICC - Verified
Recommended Usage Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 1.0 µg per mL. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details Structure An N-terminal RING-B box coiled coil (RBCC) domain most likely attributes to intermolecular structure, while two characteristic chromatin-targeting domains, a plextrin homology (PH) finger motif and bromodomain, are found in the C-terminus. Distribution Nucleus
Function TIF1β acts as a transcriptional repressor by modulating histone deacetlyation, histone H3 Ly-9 methylation, and recruitment of HP1 proteins.
Interaction TIF1β was shown to form homo-oligomers in vitro, but does not form hetero-oligomers with TIF1α or TIF1γ.
Biology Area Cell Biology, Chromatin Remodeling/Epigenetics, Transcription Factors Molecular Family Phospho-Proteins