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99
- 英文名：
Alexa Fluor® 647 anti-human CD336 (NKp44)
- 供应商：
北京云肽生物科技有限公司
BioLegend 325112 Alexa Fluor® 647 anti-human CD336 (NKp44)
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
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BioLegend 325112 Alexa Fluor® 647 anti-human CD336 (NKp44)
产品简介：
产品品牌：BioLegend
产品货号：325112
产品名称：BioLegend 325112 Alexa Fluor® 647 anti-human CD336 (NKp44)
产品规格：100 tests
产品说明：
Clone P44-8 (See other available formats)
Regulatory Status RUO
Other Names
NKp44, NCR2, Activating NK receptor NKp44, natural cytotoxicity triggering receptor 2. lymphocyte antigen 95 homolog
Isotype Mouse IgG1, κ
描述
CD336也被称为激活NK受体NKp44（NKp44），天然细胞毒性触发受体2和淋巴细胞抗原95同源物。它是一种I型跨膜蛋白，是天然细胞毒性受体家族的成员，包含一个免疫球蛋白样结构域。NKp44的表观分子量为44 kD，通过交替剪接产生三种亚型。NKp44在IL-2活化的NK细胞和γ/δ T细胞的亚群上表达。NKp44增强NK细胞介导的病毒感染细胞和肿瘤细胞的细胞溶解。NKp44已被证明与细胞内适配器DAP12相关。
CD336 is also known as activating NK receptor NKp44 (NKp44), natural cytotoxicity triggering receptor 2, and lymphocyte antigen 95 homolog. It is a type I transmembrane protein, member of the natural cytotoxicity receptor family that contains one immunoglobulin-like domain. NKp44 has an apparent molecular weight of 44 kD and three isoforms are produced by alternative splicing. NKp44 is expressed on IL-2 activated NK cells and a subset of γ/δ T cells. NKp44 enhances NK cell mediated cytolysis of virus infected cells and tumor cells. NKp44 has been shown to associate with the intracellular adaptor DAP12.
Product Details
Isotype Control
Alexa Fluor® 647 Mouse IgG1, κ Isotype Ctrl (FC)
Verified Reactivity Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type Monoclonal
Host Species Mouse
Immunogen recombinant human NKp44
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
View full statement regarding label licenses
Excitation Laser Red Laser (633 nm)
Application Notes
The p44-8 antibody against human NKp44 has been shown to be useful for flow cytometry, stimulation of human NK cells via NKp44 in a redirected lysis assay, and blocking of NKp44 function in solution. Additional reported applications (for the relevant formats) include: stimulation of human NK cells via NKp44 in a redirected lysis assay, and blocking of NKp44 function in solution1,2. The LEAF™ purified antibody (Endotoxin < 0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 325104).
Antigen Details
Structure
Type I transmembrane protein, member of the natural cytotoxicity receptor family, contains one immunoglobulin-like domain. Approximately 44 kD. Three isoforms produced by alternative splicing.
Distribution
IL-2 activated NK cells and cell lines, some γ/δ T cells activated in vitro
Function
NK cell triggering of cytolysis toward tumor targets and other target cells deficient in MHC class I molecules
Interaction DAP12
Cell Type NK cells, T cells
Biology Area Immunology
Molecular Family CD Molecules
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BioLegend 325112 Alexa Fluor® 647 anti-human CD336 (NKp44)
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