BioLegend 647501 Purified anti

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BioLegend 647501 Purified anti-XBP-1s
产品简介：
产品品牌：BioLegend
产品货号：647501
产品名称：BioLegend 647501 Purified anti-XBP-1s
产品规格：25 µg

产品说明：
Clone  143F (See other available formats)
Regulatory Status  RUO
Other Names   X-box binding protein 1
Isotype   Mouse IgG2a, κ

描述
XBP-1是一种含有bZIP结构域的转录因子。它最初被鉴定是因为它能够结合人类HLA DR基因启动子中保守的转录元件X-box。XBP-1具有多种功能。它控制MHC II类基因调控，也是浆细胞分化所必需的。XBP-1作为ER应激反应的一部分上调，也称为未折叠蛋白反应。未剪接的XBP-1为261个氨基酸，在SDS-PAGE上迁移约33kD；被克隆143F识别的剪接XBP-1是371个氨基酸，并且迁移大约55kD。
XBP-1 is a transcription factor containing a bZIP domain. It was first identified because of its ability to bind X-box, a conserved transcriptional element in the promoter of human HLA DR gene. XBP-1 has multiple functions. It controls MHC class II gene regulation and is also essential for differentiation of plasma cells. XBP-1 upregulates as part of the ER stress response, also known as the unfolded protein response. Unspliced XBP-1 is 261 amino acids and migrates on the SDS-PAGE around 33 kD; spliced XBP-1, recognized by clone 143F, is 371 amino acids and migrates around 55 kD.

Product Details
Isotype Control
Go-ChIP-Grade™ Purified Mouse IgG2a, κ Isotype Ctrl
Verified Reactivity   Human
Antibody Type   Monoclonal
Host Species   Mouse
Immunogen   XBP-1s recombinant protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation
The antibody was purified by affinity chromatography.
Concentration   0.5 mg/mL

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application   WB - Quality tested
ChIP - Verified
ICC, IHC-P - Reported in the literature, not verified in house

Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 to 2.0 µg per mL. For ChIP application, use 2 µg of antibody per 10 µg of chromatin per IP. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details
Distribution  Ubiquitously expressed.
Function
Upregulated by ER stress, IL-6, and IL-4. Downregulation correlates with tumor progression in prostate cancer. Downregulated by PAX5 transcription factor.
Biology Area   Cell Biology

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