BioLegend 613415 APC anti-H2A.

北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。

美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
BioLegend 公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。

BioLegend 613415 APC anti-H2A.X Phospho (Ser139)
产品简介：
产品品牌：BioLegend
产品货号：613415
产品名称：BioLegend 613415 APC anti-H2A.X Phospho (Ser139)
产品规格：25 tests

产品说明：
Clone   2F3 (See other available formats)
Regulatory Status  RUO
Other Names
H2A.x, H2a/x, Histone 2A, Histone 2A.X, Gamma-H2AX
Isotype   Mouse IgG1, κ

描述
H2A.X是14kD的基础组蛋白，也是H2组蛋白家族的成员。这种核蛋白是在细胞周期的G1和S期合成的，已知对DNA修复和维持基因组稳定性以及免疫球蛋白转换区之间的重组很重要。H2A.X在双链DNA断裂后在丝氨酸139上被磷酸化。磷酸化H2A.X促进DNA修复并保持基因组稳定性。2F3单克隆抗体与磷酸化的人H2A.X（Ser139）反应，并已被证明可用于蛋白质印迹、免疫荧光和流式细胞术。
H2A.X is a 14 kD basal histone and a member of the H2 histone family. This nuclear protein is synthesized in the G1 and S phase of the cell cycle and is known to be important for DNA repair and maintaining genomic stability and for recombination between immunoglobulin switch regions. H2A.X becomes phosphorylated on serine 139 after double-stranded DNA breaks. Phosphorylated H2A.X promotes DNA repair and maintains genomic stability. The 2F3 monoclonal antibody reacts with phosphorylated human H2A.X (Ser139) and has been shown to be useful for Western blotting, immunofluorescence and flow cytometry.

Product Details
Isotype Control   APC Mouse IgG1, κ Isotype Ctrl (ICFC)
Verified Reactivity   Human, Mouse
Antibody Type   Monoclonal
Host Species   Mouse
Immunogen   Modified peptide
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.

Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application   ICFC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Antigen Details
Structure   Basal histone, H2 histone family; 14 kD
Distribution   Nuclear
Function
Phosphorylated H2AX promotes DNA repair and maintains genomic stability. Important for recombination between immunoglobulin switch regions

Modification
Phosphorylation on Ser139 after double-stranded DNA breaks

Biology Area
Cell Biology, Chromatin Remodeling/Epigenetics, DNA Repair/Replication, Neuroscience
Molecular Family   Phospho-Proteins

以下是 BioLegend 品牌部分产品，如需其他产品请联系本公司销售。
BioLegend 400312 PE Mouse IgG2b, κ Isotype Ctrl   MPC-11    100 ug
BioLegend 400313 PE Mouse IgG2b, κ Isotype Ctrl   MPC-11    25 tests
BioLegend 400314 PE Mouse IgG2b, κ Isotype Ctrl   MPC-11    100 tests
BioLegend 400318 PE/Cyanine5 Mouse IgG2b, κ Isotype Ctrl    MPC-11    100 tests
BioLegend 400319 APC Mouse IgG2b, κ Isotype Ctrl      MPC-11    25 ug
BioLegend 400320 APC Mouse IgG2b, κ Isotype Ctrl      MPC-11    100 ug
BioLegend 400321 APC Mouse IgG2b, κ Isotype Ctrl      MPC-11    25 tests
BioLegend 400322 APC Mouse IgG2b, κ Isotype Ctrl      MPC-11    100 tests
BioLegend 400325 PE/Cyanine7 Mouse IgG2b, κ Isotype Ctrl    MPC-11    25 tests
BioLegend 400326 PE/Cyanine7 Mouse IgG2b, κ Isotype Ctrl    MPC-11    100 tests
BioLegend 400328 APC/Cyanine7 Mouse IgG2b, κ Isotype Ctrl MPC-11    100 tests
BioLegend 400329 Alexa Fluor® 488 Mouse IgG2b, κ Isotype Ctrl   MPC-11    100 tests
BioLegend 400330 Alexa Fluor® 647 Mouse IgG2b, κ Isotype Ctrl   MPC-11    100 ug
BioLegend 400331 Pacific Blue™ Mouse IgG2b, κ Isotype Ctrl    MPC-11    100 ug
BioLegend 400337 PerCP/Cyanine5.5 Mouse IgG2b, κ Isotype Ctrl  MPC-11    25 tests
BioLegend 400338 PerCP/Cyanine5.5 Mouse IgG2b, κ Isotype Ctrl  MPC-11    100 tests
BioLegend 400341 Brilliant Violet 421™ Mouse IgG2b, κ Isotype Ctrl    MPC-11    25 tests
BioLegend 400342 Brilliant Violet 421™ Mouse IgG2b, κ Isotype Ctrl    MPC-11    100 tests
BioLegend 400345 Brilliant Violet 510™ Mouse IgG2b, κ Isotype Ctrl    MPC-11    25 tests
BioLegend 400346 Brilliant Violet 510™ Mouse IgG2b, κ Isotype Ctrl    MPC-11    100 tests
BioLegend 400348 Ultra-LEAF™ Purified Mouse IgG2b, κ Isotype Ctrl   MPC-11    1 mg
BioLegend 400349 Brilliant Violet 605™ Mouse IgG2b, κ Isotype Ctrl    MPC-11    25 tests