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- 文献和实验
- 技术资料
- 库存：
99
- 英文名：
Purified anti-HDAC1 Phospho (Ser406)
- 供应商：
北京云肽生物科技有限公司
BioLegend 611002 Purified anti-HDAC1 Phospho (Ser406)
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
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BioLegend 611002 Purified anti-HDAC1 Phospho (Ser406)
产品简介：
产品品牌：BioLegend
产品货号：611002
产品名称：BioLegend 611002 Purified anti-HDAC1 Phospho (Ser406)
产品规格：100 µg
产品说明：
Clone BT-15 (See other available formats)
Regulatory Status RUO
Other Names Histone Deactylase 1, RPD3L1
Isotype Mouse IgG2b, κ
描述
组蛋白脱乙酰酶1（HDAC1）在各种细胞过程中起着关键作用，包括细胞周期的进展、增殖和分化。该酶的作用是从组蛋白靶标上去除乙酰基部分，导致组蛋白压实和核小体定位的改变。Aurora激酶在细胞开始有丝分裂后的前期将HDAC1磷酸化Ser406，导致HDAC1的脱乙酰酶活性降低。这种修饰在调节细胞周期进展以及控制参与中枢神经系统发育的基因表达方面发挥着重要作用。
Histone Deacetylase 1 (HDAC1) plays a critical role in various cellular processes, including cell cycle progression, proliferation, and differentiation. The enzyme functions by removing acetyl moieties from histone targets, resulting in histone compaction and alterations in nucleosomal positioning. Aurora kinases phosphorylate HDAC1 at Ser406 during prophase, immediately after cells begin mitosis, resulting in reduced deacetylase activity of HDAC1. This modification plays an essential role in regulating cell cycle progression, as well as controlling the expression of genes involved in central nervous system development.
Product Details
Isotype Control Purified Mouse IgG2b, κ Isotype Ctrl
Verified Reactivity Human, Zebrafish
Antibody Type Monoclonal
Host Species Mouse
Immunogen
Synthetic peptide corresponding to human HDAC1 phosphorylated at Serine 406
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration 0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application WB - Quality tested
ICFC - Verified
Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 1.0 µg per ml. For intracellular flow cytometry using our True-Phos™ Perm Buffer in Cell Suspensions Protocol, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details
Structure
HDAC1 is a 482 amino acid protein with a predicted molecular weight of 55 kD.
Distribution Nucleus/Ubiquitously expressed
Function
Phosphorylation of HDAC1 Ser406 results in reduced deactylase activity of the enzyme.
Biology Area
Cell Biology, Cell Cycle/DNA Replication, Chromatin Remodeling/Epigenetics
Molecular Family Nuclear Markers, Phospho-Proteins
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文献和实验相关实验
Using Phospho‐Motif Antibodies to Determine Kinase Substrates
Figure 18.20.1 The specificity of phospho‐motif antibodies. HeLa cells were serum‐starved for 24 hr prior to being stimulated with 50 ng/ml IGF‐1 or 100 nM PMA for 10 min. Lysates were immunoblotted with anti‐Akt/PKB phospho‐motif (left panel
：使用 Anti-phospho-Akt (Ser473) Rabbit mAb 对石蜡包埋的人乳腺癌组织进行免疫组织化学分析。（图 A）使用免疫组化试剂盒M&R HRP/DAB Detection IHC Kit，抗体 1:100 稀释；(图 B) 采用普通免疫组化试剂盒，抗体 1:25 稀释。 图 6 免疫组化实验检测 Erk1/2 表达 注：使用 Anti-Erk1/2 Mouse mAb与p44/42 MAPK （Erk1/2）Rabbit mAb 对正常小鼠心脏组织进行免疫
at 10, 25, and 50 μM). At 24 h post-treatment, celllysates were obtained; SDS-PAGE and Western blotting were performed as described in Section 3, Methods. AR-A014418dose-dependent decreases of phospho-β-catenin (Ser33/37) and phospho-glycogen synthase
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BioLegend 611002 Purified anti-HDAC1 Phospho (Ser406)
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