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- 英文名：
BioLegend 438307 LEGEND MAX™ Human anti-mouse Ig (HAMA) ELISA Kit
- 供应商：
北京云肽生物科技有限公司
BioLegend 438307 LEGEND MAX™ Human anti-mouse Ig (HAMA) ELISA Kit
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
BioLegend 公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 438307 LEGEND MAX™ Human anti-mouse Ig (HAMA) ELISA Kit
产品简介：
产品品牌：BioLegend
产品货号：438307
产品名称：BioLegend 438307 LEGEND MAX™ Human anti-mouse Ig (HAMA) ELISA Kit
产品规格：1 Pre-coated Plate
产品说明：
Regulatory Status RUO
Other Names
Human anti-mouse antibodies (HAMA) Pre-coated ELISA Kit
描述
人抗小鼠抗体，也称为HAMA，是在人血清中发现的抗体，具有与小鼠免疫球蛋白结合的能力。在大约5-10%的正常人群中检测到预先存在的HAMA活性，这被认为是由暴露于小鼠或小鼠制剂引起的。小鼠单克隆抗体或小鼠单克隆抗体衍生产品的治疗用途正在成为患者血清中HAMA活性的最常见原因。在治疗、检测开发和诊断领域，越来越需要确定人血清样品中 HAMA 的水平。例如，在治疗领域，响应于注射的单克隆抗体产生的HAMA不仅能结合并降低治疗剂的疗效，而且能引起随后给予小鼠单克隆抗体的过敏并发症。因此，它可用于监测接受小鼠单克隆抗体治疗的患者的预后。此外，HAMA由于其结合小鼠IgG的性质，倾向于在Sandwich ELISA中引起假阳性结果或在利用小鼠单克隆抗体的竞争性免疫测定中引起假阴性结果。在出现意外的免疫测定结果时，测量血清样品中的 HAMA 非常重要。
BioLegend的LEGEND MAX™人抗小鼠Ig（HAMA）ELISA试剂盒是一种夹心酶联免疫吸附测定（ELISA），其中小鼠Ig预包被在96孔条板上。BioLegend 的 LEGEND MAX™ 人抗小鼠 Ig （HAMA） ELISA 试剂盒专为准确定量血清和血浆中的人抗小鼠 Ig 而设计。它即用型、准确且灵敏。
Description
Human anti-mouse antibodies, also known as HAMA, are antibodies found in human serum which have the ability to bind to mouse immunoglobulin. Pre-existing HAMA activity has been detected in approximately 5-10% of normal populations, which is believed to be caused by exposure to mice or mouse agents. Therapeutic use of mouse monoclonal antibodies or products derived from mouse monoclonal antibodies are becoming the most common cause of HAMA activities in patient serum. There is an increasing need to determine the levels of HAMA in human serum samples in the therapeutic, assay development, and diagnostic areas. For example, in the therapeutic area, HAMA generated in response to injected monoclonal antibodies not only can bind and reduce the efficacy of the therapeutics, but also can cause anaphylactic complications to subsequent administration of mouse monoclonal antibodies. Therefore, it is useful for monitoring the prognosis of patients that received a mouse monoclonal antibody treatment. In addition, HAMA due to its nature to bind mouse IgG, tend to cause false positive results in Sandwich ELISA or false negative results in competitive immunoassays utilizing mouse monoclonal antibodies. It is important to measure serum samples for HAMA in case of unexpected immunoassay results. BioLegend’s LEGEND MAX™ Human Anti-Mouse Ig (HAMA) ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (ELISA), in which, mouse Ig is pre-coated on a 96-well strip-well plate. BioLegend’s LEGEND MAX™ Human Anti-Mouse Ig (HAMA) ELISA Kit is specifically designed for the accurate quantitation of Human anti-mouse Ig from serum and plasma. It is ready-to-use, accurate, and sensitive.
Product Details
Verified Reactivity Human
Application ELISA
Antigen Details
Biology Area Immunology
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BioLegend 438307 LEGEND MAX™ Human anti-mouse Ig (HAMA) ELISA Kit
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