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- 英文名：
BioLegend 436207 LEGEND MAX™ Mouse IL-17A/F ELISA Kit
- 供应商：
北京云肽生物科技有限公司
BioLegend 436207 LEGEND MAX™ Mouse IL-17A/F ELISA Kit
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
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BioLegend 436207 LEGEND MAX™ Mouse IL-17A/F ELISA Kit
产品简介：
产品品牌：BioLegend
产品货号：436207
产品名称：BioLegend 436207 LEGEND MAX™ Mouse IL-17A/F ELISA Kit
产品规格：1 Pre-coated Plate
产品说明：
Regulatory Status RUO
Other Names IL-17A/F Pre-coated ELISA Kit
描述
IL-17A/F是IL-17A和IL-17F的异二聚体，IL-17家族中研究最多的两个成员，由至少六种促炎细胞因子组成。在IL-17家族成员中，IL-17A和IL-17F具有最高的序列同源性，为50%，并且它们位于同一染色体区域。 早期的研究表明，IL-17A和IL-17F都是由Th17细胞（CD4 + T细胞的活化亚群）作为同源二聚体产生的。 然而，最近的研究表明，IL-17A/F异二聚体也在Th17细胞中产生，作为一种40 kD的分泌二硫键糖蛋白。
在功能上，IL-17A/F异二聚体通过与IL-17A和IL-17F同源二聚体相同的受体发出信号，并诱导类似的生物学反应。然而，小鼠和人类IL-17A的生物活性都比IL-17F高100倍以上，而IL-17A/F具有中间活性。 IL-17A 和 IL-17F 都与人类的许多炎症性疾病有关，例如类风湿性关节炎、多发性硬化症、牛皮癣、炎症性肠病和哮喘。 IL-17A/F的确切细胞功能及其在疾病过程中的作用仍然不是很清楚。方便且即用型的IL-17A/F试剂盒对于参与IL-17A、IL-17F和IL-17A/F研究工作的人来说将是一个非常有用的工具。
BioLegend的LEGEND MAX™小鼠IL-17A / F ELISA试剂盒是一种夹心酶联免疫吸附测定（ELISA），其中小鼠IL-17A特异性单克隆抗体预包被在96孔条板上。
BioLegend 的 LEGEND MAX™ 小鼠 IL-17A/F ELISA 试剂盒专为准确定量来自细胞培养上清液、血清、血浆或其他体液的小鼠 IL-17A/F 而设计。它即用型、准确、灵敏且经济高效。
IL-17A/F is a heterodimer of IL-17A and IL-17F, two of the most studied members of the IL-17 family, consisting of at least six proinflammatory cytokines. Among the IL-17 family members, IL-17A and IL-17F share the highest sequence homology of 50%, and they are located on the same chromosome region. Earlier studies have shown that both IL-17A and IL-17F are produced as homodimers by Th17 cells, an activated subset of CD4+ T cells. However, recent studies demonstrate that the IL-17A/F heterodimer is also produced in Th17 cells, as a 40 kD, secreted, disulfide-linked glycoprotein.
Functionally, IL-17A/F heterodimers signal through the same receptor as IL-17A and IL-17F homodimers and induce similar biological responses. However, both mouse and human IL-17A demonstrate more than 100-fold higher biological activity than IL-17F, while IL- 17A/F has intermediate activity. Both IL-17A and IL-17F have been associated with many inflammatory diseases in humans such as rheumatoid arthritis, multiple sclerosis, psoriasis, inflammatory bowel disease, and asthma. The exact cellular functions of IL-17A/F and its role in the disease processes are still not very clear. A convenient and ready-to-use IL-17A/F kit will be a very useful tool for those involved in the IL-17A, IL-17F, and IL-17A/F research efforts.
BioLegend’s LEGEND MAX™ Mouse IL-17A/F ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (ELISA), in which a Mouse IL-17A specific monoclonal antibody is pre-coated on a 96-well strip-well plate.
BioLegend’s LEGEND MAX™ Mouse IL-17A/F ELISA Kit is specifically designed for the accurate quantitation of mouse IL-17A/F from cell culture supernatant, serum, plasma, or other bodily fluids. It is ready-to-use, accurate, sensitive, and cost-effective.
Product Details
Verified Reactivity Mouse
Application ELISA
Antigen Details
Cell Sources Th17 cells, an activated subset of CD4+ T cells
Biology Area
Immunology, Neuroinflammation, Neuroscience
Molecular Family Cytokines/Chemokines
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BioLegend 436207 LEGEND MAX™ Mouse IL-17A/F ELISA Kit
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