产品说明: Regulatory Status RUO Other Names IL-27 Pre-coated ELISA Kit
描述 人IL-27是IL-12细胞因子家族的成员,是由EBI3(EB病毒诱导的基因3)和p28蛋白组成的异二聚体蛋白。它在幼稚CD4 + T细胞和自然杀伤细胞上表达。IL-27 由抗原呈递细胞产生,以诱导幼稚 CD4+ T 细胞的增殖,并通过 STAT1 激活人单核细胞,此外还抑制 IL-10 的产生。IL-27通过孤儿细胞因子受体WSX-1 / TCCR介导其生物学效应。IL-27与IL-12强协同支持IFN-?幼稚CD4 + T细胞的产生和分化为辅助性T细胞。 BioLegend 的 LEGEND MAX™ 人 IL-27 ELISA 试剂盒是一种夹心酶联免疫吸附测定 (ELISA),其中将人 IL-27 特异性单克隆抗体预包被在 96 孔条孔板上。 BioLegend 的 LEGEND MAX™ 人 IL-27 ELISA 试剂盒专为准确定量来自细胞培养上清液、血清、血浆或其他体液的人 IL-27 而设计。它即用型、准确且灵敏。 Human IL-27 is a member of the IL-12 cytokine family and is a heterodimeric protein composed of EBI3 (Epstein-Barr virus-induced gene 3) and p28 protein. It is expressed on naïve CD4+ T cells and natural killer cells. IL-27 is produced by antigen-presenting cells to induce proliferation of naive CD4+ T cells and activates human monocytes via STAT1 in addition to suppressing IL-10 production. IL-27 mediates its biological effects through the orphan cytokine receptor WSX-1/TCCR. IL-27 strongly synergizes with IL-12 to support IFN-? production and differentiation of naive CD4+ T cells into T helper type.
BioLegend’s LEGEND MAX™ Human IL-27 ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (ELISA), in which, a Human IL-27 specific monoclonal antibody is pre-coated on a 96-well strip-well plate.
BioLegend’s LEGEND MAX™ Human IL-27 ELISA Kit is specifically designed for the accurate quantitation of Human IL-27 from cell culture supernatant, serum, plasma or other bodily fluids. It is ready-to-use, accurate, and sensitive.
Product Details Verified Reactivity Human Application ELISA
Antigen Details Cell Sources Naïve CD4+ T cells and natural killer cells Biology Area Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Signal Transduction Molecular Family Cytokines/Chemokines