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- 文献和实验
- 技术资料
- 库存：
99
- 英文名：
Purified anti-mouse CD279 (PD-1)
- 供应商：
北京云肽生物科技有限公司
BioLegend 114101Purified anti-mouse CD279 (PD-1)
北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国BioLegend公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend虽然成立的时间不长，但它聚集了一批来自PharMingen公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。BioLegend公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 114101 Purified anti-mouse CD279 (PD-1)
产品简介：
产品品牌：BioLegend
产品货号：114101
产品名称：BioLegend 114101 Purified anti-mouse CD279 (PD-1)
产品规格：50 µg
产品说明：
Clone RMP1-14 (See other available formats)
Regulatory Status RUO
Other Names Programmed Death-1, CD279, PD 1
Isotype Rat IgG2a, κ
描述
CD279是一个50-55kD的免疫球蛋白超家族成员，也称为程序性死亡-1（PD-1）。PD-1在CD4-CD8-胸腺细胞亚群以及活化的T细胞和B细胞上表达。PD-1被认为参与淋巴细胞克隆选择和外周耐受。PD-1配体PD-L1（也称为B7-H1）和PD-L2（B7-DC）是B7免疫球蛋白超家族的成员。据报道，RMP1-14抗体阻断PD-1与其配体（B7-H1和B7-DC）的结合，并抑制巨噬细胞（但不是树突状细胞和B细胞）共刺激的T细胞增殖和细胞因子产生。
CD279 is a 50-55 kD immunoglobulin superfamily member, also known as programmed death-1 (PD-1). PD-1 is expressed on a subset of CD4-CD8- thymocytes, and on activated T and B cells. PD-1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. The RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production costimulated by macrophages (but not by dendritic cells and B cells).
Product Details
Isotype Control Purified Rat IgG2a, κ Isotype Ctrl
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen Mouse PD-1 transfected BHK cells
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography.
Concentration 0.5 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze."
Application FC - Quality tested
IHC, WB, FA - Reported in the literature, not verified in house
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes
Additional reported applications (for relevant formats of this clone) include: immunohistochemical staining of*-fixed frozen sections1, Western blotting2,6, inhibition of macrophages (but not B cells and dendritic cells) costimulated T cell proliferation3,5, and blocking the binding of PD-1 to B7-H1 or B7-DC3,4,8. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 114108). For highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 114110) with a lower endotoxin limit than standard LEAF™ purified antibodies.
Antigen Details
Structure Ig superfamily, 50-55 kD
Distribution
Subset of double negative thymocytes, activated T and B cells
Function Lymphocyte clonal selection, peripheral tolerance
Ligand/Receptor PD-L1 (B7-H1), PD-L2
Cell Type B cells, T cells, Thymocytes, Tregs
Biology Area Apoptosis/Tumor Suppressors/Cell Death, Cancer Biomarkers, Cell Biology, Immunology, Inhibitory Molecules
Molecular Family CD Molecules, Immune Checkpoint Receptors
以下是BioLegend 品牌部分产品，如需其他产品请联系本公司销售。
BioLegend 102413 Alexa Fluor® 488 anti-mouse CD31 390 25 ug
BioLegend 102414 Alexa Fluor® 488 anti-mouse CD31 390 100 ug
BioLegend 102415 Alexa Fluor® 647 anti-mouse CD31 390 25 ug
BioLegend 102416 Alexa Fluor® 647 anti-mouse CD31 390 100 ug
BioLegend 102419 PerCP/Cyanine5.5 anti-mouse CD31 390 25 ug
BioLegend 102420 PerCP/Cyanine5.5 anti-mouse CD31 390 100 ug
BioLegend 102421 Pacific Blue™ anti-mouse CD31 390 25 ug
BioLegend 102425 Purified anti-mouse CD31 (Maxpar® Ready) 390 100 ug
BioLegend 102427 Brilliant Violet 605™ anti-mouse CD31 390 50 ug
BioLegend 102434 APC/Fire™ 750 anti-mouse CD31 390 100 ug
BioLegend 102437 TotalSeq™-A0904 anti-mouse CD31 390 10 ug
BioLegend 102437 TotalSeq™-A0904 anti-mouse CD31 390 10 ug
BioLegend 102440 APC/Cyanine7 anti-mouse CD31 390 100 ug
BioLegend 102444 Alexa Fluor® 700 anti-mouse CD31 390 100 ug
BioLegend 102449 Brilliant Violet 711™ anti-mouse CD31 390 50 ug
BioLegend 102501 Purified anti-mouse CD31 MEC13.3 50 ug
BioLegend 102502 Purified anti-mouse CD31 MEC13.3 500 ug
BioLegend 102503 Biotin anti-mouse CD31 MEC13.3 50 ug
BioLegend 102504 Biotin anti-mouse CD31 MEC13.3 500 ug
BioLegend 102506 FITC anti-mouse CD31 MEC13.3 500 ug
BioLegend 102507 PE anti-mouse CD31 MEC13.3 50 ug
BioLegend 102508 PE anti-mouse CD31 MEC13.3 200 ug
北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国BioLegend公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend虽然成立的时间不长，但它聚集了一批来自PharMingen公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。BioLegend公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 114101 Purified anti-mouse CD279 (PD-1)
产品简介：
产品品牌：BioLegend
产品货号：114101
产品名称：BioLegend 114101 Purified anti-mouse CD279 (PD-1)
产品规格：50 µg
产品说明：
Clone RMP1-14 (See other available formats)
Regulatory Status RUO
Other Names Programmed Death-1, CD279, PD 1
Isotype Rat IgG2a, κ
描述
CD279是一个50-55kD的免疫球蛋白超家族成员，也称为程序性死亡-1（PD-1）。PD-1在CD4-CD8-胸腺细胞亚群以及活化的T细胞和B细胞上表达。PD-1被认为参与淋巴细胞克隆选择和外周耐受。PD-1配体PD-L1（也称为B7-H1）和PD-L2（B7-DC）是B7免疫球蛋白超家族的成员。据报道，RMP1-14抗体阻断PD-1与其配体（B7-H1和B7-DC）的结合，并抑制巨噬细胞（但不是树突状细胞和B细胞）共刺激的T细胞增殖和细胞因子产生。
CD279 is a 50-55 kD immunoglobulin superfamily member, also known as programmed death-1 (PD-1). PD-1 is expressed on a subset of CD4-CD8- thymocytes, and on activated T and B cells. PD-1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. The RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production costimulated by macrophages (but not by dendritic cells and B cells).
Product Details
Isotype Control Purified Rat IgG2a, κ Isotype Ctrl
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen Mouse PD-1 transfected BHK cells
Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography.
Concentration 0.5 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze."
Application FC - Quality tested
IHC, WB, FA - Reported in the literature, not verified in house
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes
Additional reported applications (for relevant formats of this clone) include: immunohistochemical staining of*-fixed frozen sections1, Western blotting2,6, inhibition of macrophages (but not B cells and dendritic cells) costimulated T cell proliferation3,5, and blocking the binding of PD-1 to B7-H1 or B7-DC3,4,8. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 114108). For highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 114110) with a lower endotoxin limit than standard LEAF™ purified antibodies.
Antigen Details
Structure Ig superfamily, 50-55 kD
Distribution
Subset of double negative thymocytes, activated T and B cells
Function Lymphocyte clonal selection, peripheral tolerance
Ligand/Receptor PD-L1 (B7-H1), PD-L2
Cell Type B cells, T cells, Thymocytes, Tregs
Biology Area Apoptosis/Tumor Suppressors/Cell Death, Cancer Biomarkers, Cell Biology, Immunology, Inhibitory Molecules
Molecular Family CD Molecules, Immune Checkpoint Receptors
以下是BioLegend 品牌部分产品，如需其他产品请联系本公司销售。
BioLegend 102413 Alexa Fluor® 488 anti-mouse CD31 390 25 ug
BioLegend 102414 Alexa Fluor® 488 anti-mouse CD31 390 100 ug
BioLegend 102415 Alexa Fluor® 647 anti-mouse CD31 390 25 ug
BioLegend 102416 Alexa Fluor® 647 anti-mouse CD31 390 100 ug
BioLegend 102419 PerCP/Cyanine5.5 anti-mouse CD31 390 25 ug
BioLegend 102420 PerCP/Cyanine5.5 anti-mouse CD31 390 100 ug
BioLegend 102421 Pacific Blue™ anti-mouse CD31 390 25 ug
BioLegend 102425 Purified anti-mouse CD31 (Maxpar® Ready) 390 100 ug
BioLegend 102427 Brilliant Violet 605™ anti-mouse CD31 390 50 ug
BioLegend 102434 APC/Fire™ 750 anti-mouse CD31 390 100 ug
BioLegend 102437 TotalSeq™-A0904 anti-mouse CD31 390 10 ug
BioLegend 102437 TotalSeq™-A0904 anti-mouse CD31 390 10 ug
BioLegend 102440 APC/Cyanine7 anti-mouse CD31 390 100 ug
BioLegend 102444 Alexa Fluor® 700 anti-mouse CD31 390 100 ug
BioLegend 102449 Brilliant Violet 711™ anti-mouse CD31 390 50 ug
BioLegend 102501 Purified anti-mouse CD31 MEC13.3 50 ug
BioLegend 102502 Purified anti-mouse CD31 MEC13.3 500 ug
BioLegend 102503 Biotin anti-mouse CD31 MEC13.3 50 ug
BioLegend 102504 Biotin anti-mouse CD31 MEC13.3 500 ug
BioLegend 102506 FITC anti-mouse CD31 MEC13.3 500 ug
BioLegend 102507 PE anti-mouse CD31 MEC13.3 50 ug
BioLegend 102508 PE anti-mouse CD31 MEC13.3 200 ug
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BioLegend 114101Purified anti-mouse CD279 (PD-1)
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