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99
- 英文名：
APC/Cyanine7 anti-human CD192 (CCR2)
- 供应商：
北京云肽生物科技有限公司
BioLegend 357219 APC/Cyanine7 anti-human CD192 (CCR2)
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
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BioLegend 357219 APC/Cyanine7 anti-human CD192 (CCR2)
产品简介：
产品品牌：BioLegend
产品货号：357219
产品名称：BioLegend 357219 APC/Cyanine7 anti-human CD192 (CCR2)
产品规格：25 tests
产品说明：
Clone K036C2 (See other available formats)
Regulatory Status RUO
Other Names
CKR2, CCR2A, CCR2B, CKR2A, CKR2B, CMKBR2, MCP-1-R, CC-CKR-2
Isotype Mouse IgG2a, κ
描述
CCR2是一种趋化因子受体，可结合单核细胞化学引诱蛋白（MCP-1，2，3和4）。最初描述了CCR2的两种剪接变体（CCR2A和CCR2B）。这些变体的末端羧基尾巴不同。单核细胞粘附在动脉内皮上并随后迁移到内膜是动脉粥样硬化发病机制的核心事件。CCR2 和 MCP-1 与动脉粥样硬化斑块相关。MCP-1由内皮细胞中的修饰LDL诱导，在流动条件下可能触发单核细胞与血管内皮的牢固粘附。MCP-1在血管壁的局部过表达诱导巨噬细胞浸润并形成动脉粥样硬化病变。肥胖诱发炎症状态，与许多临床上重要的并发症有关，包括胰岛素抵抗、糖尿病、动脉粥样硬化和非酒精性脂肪性肝病。CCR2影响肥胖和相关脂肪组织炎症的发展。
CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4). Two spliced variants were initially described for CCR2 (CCR2A and CCR2B). These variants differ in their terminal carboxyl tails. Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 have been associated to atherosclerotic plaques. MCP-1 is induced by modified-LDL in endothelial cells and may trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Local overexpression of MCP-1 at vessel walls induces infiltration of macrophages and formation of atherosclerotic lesions. Obesity induces an inflammatory state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation.
Product Details
Isotype Control APC/Cyanine7 Mouse IgG2a, κ Isotype Ctrl
Verified Reactivity Human
Antibody Type Monoclonal
Host Species Mouse
Immunogen CCR2 DNA immunogen
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser Red Laser (633 nm)
Application Notes
Epitope of clone K036C2 has been mapped to amino acids 11-29 and 21-39 of human CCR2.
Additional Product Notes
BioLegend is in the process of converting the name APC/Cy7 to APC/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our APC/Cyanine7 products. Please contact Technical Service if you have any questions.
Antigen Details
Structure
Chemokine receptor, GPCR, seven transmembrane receptor
Distribution
Monocytes, macrophages, immature dendritic cells, memory T cells
Function
Induces monocyte adhesion to endothelial cells and chemotaxis
Ligand/Receptor
CCL2 (MCP-1), CCL7 (MCP-3), CCL8 (MCP-2), CCL13 (MCP-4), CCL16 (HCC4)
Cell Type Dendritic cells, Macrophages, Monocytes, T cells
Biology Area
Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
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BioLegend 357219 APC/Cyanine7 anti-human CD192 (CCR2)
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