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- 详细信息
- 技术资料
- 库存：
大量
- 英文名：
APC/Cyanine7 anti-human CD64 Antibody
- CAS号：
APC/Cyanine7 anti-human CD64 Antibody
- 保质期：
详见说明
- 供应商：
齐源生物
- 保存条件：
2-8℃
- 规格：
25 tests/100 tests
| 规格： | 25 tests | 产品价格： | ￥2500.0 |
|---|---|---|---|
| 规格： | 100 tests | 产品价格： | ￥6100.0 |
APC/Cyanine7 抗人 CD64 抗体、APC/Cyanine7 anti-human CD64 Antibody详细如下：
Other Names：FcγRI, FcR I
Isotype：Mouse IgG1, κ
Description：
CD64 is a 72 kD single chain type I glycoprotein also known as FcγRI and FcR I. CD64 is a member of the immunoglobulin superfamily and is expressed on monocytes/macrophages, dendritic cells, and activated granulocytes. The expression can be upregulated by IFN-γ stimulation. CD64 binds IgG immune complex. It plays a role in antigen capture, phagocytosis of IgG/antigen complexes, and antibody-dependent cellular cytotoxicity (ADCC).
Isotype Control：APC/Cyanine7 Mouse IgG1, κ Isotype Ctrl
Reactivity：Human, Baboon, Capuchin Monkey, Chimpanzee, Cynomolgus, Rhesus, Squirrel Monkey
Antibody Type：Monoclonal
Host Species：Mouse
Immunogen：Human rheumatoid synovial fluid cells and fibronectin-purified monocytes.
Formulation：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Preparation：The antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions.
Concentration：Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling：The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application：FC - Quality tested
Recommended Usage：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser：Red Laser (633 nm)
Application Notes：Clone 10.1 recognizes the EC3 epitope of CD64. While both contain the EC3 domain, in-house testing suggests that clone 10.1 preferentially binds to CD64A (FcγRIA), but not CD64B (FcγRIB). Additional reported applications (for the relevant formats) include: blocking of human IgG3 and murine IgG2a binding to FcγRI2,5,6,11 and immunohistochemical staining of acetone-fixed frozen tissue sections12.
Additional Product Notes：BioLegend is in the process of converting the name APC/Cy7 to APC/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our APC/Cyanine7 products. Please contact Technical Service if you have any questions.
Application References：
1.McMichael A, et al. Eds. 1987. Leucocyte Typing III. Oxford University Press. New York.
2.Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. p. 874.
3.Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London.
4.Holl V, et al. 2004. J. Immunol. 173:6274.
5.Hober D, et al. 2002. J. Gen. Virol. 83:2169.
6.Cho HJ, et al. 2007. Physiol Genomics 149:60.
7.van Tits L, et al. 2005. Arterioscler Thromb Vasc Biol. 25:717. PubMed
8.Bruhns P, et al. 2008. Blood 113:3716. PubMed
9.Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
10.Carter DL, et al. 1999. Cytometry 37:41. (FC)
11.Dougherty GJ, et al. 1987. Eur. J. Immunol. 17:1453.
12.Blom AB, et al. 2003. Arthritis Rheum. 48(4):1002-14. (IHC)
Product Citations：
1.Cassetta L et al. 2019. Cancer Cell. 35(4):588-602 . PubMed
2.Santra S, et al. 2015. PLoS Pathog. 11: 1005042. PubMed
3.Quast I, et al. 2015. Neurol Neuroimmunol Neuroinflamm. 2: e148. PubMed
Structure：Ig superfamily, type I glycoprotein, 72 kD
Distribution：Monocytes, macrophages, dendritic cells, activated granulocytes
Function：Phagocytosis, ADCC
Ligand/Receptor：IgG receptor
Cell Type：Dendritic cells, Granulocytes, Macrophages, Monocytes
Biology Area：Immunology, Innate Immunity
Molecular Family：CD Molecules, Fc Receptors
Antigen References：
1. Hulett M, et al. 1994. Adv. Immunol. 57:1.
2. van de Winkel J, et al. 1993. Immunol. Today 14:215.
Other Names：FcγRI, FcR I
Isotype：Mouse IgG1, κ
Description：
CD64 is a 72 kD single chain type I glycoprotein also known as FcγRI and FcR I. CD64 is a member of the immunoglobulin superfamily and is expressed on monocytes/macrophages, dendritic cells, and activated granulocytes. The expression can be upregulated by IFN-γ stimulation. CD64 binds IgG immune complex. It plays a role in antigen capture, phagocytosis of IgG/antigen complexes, and antibody-dependent cellular cytotoxicity (ADCC).
Isotype Control：APC/Cyanine7 Mouse IgG1, κ Isotype Ctrl
Reactivity：Human, Baboon, Capuchin Monkey, Chimpanzee, Cynomolgus, Rhesus, Squirrel Monkey
Antibody Type：Monoclonal
Host Species：Mouse
Immunogen：Human rheumatoid synovial fluid cells and fibronectin-purified monocytes.
Formulation：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Preparation：The antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions.
Concentration：Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling：The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application：FC - Quality tested
Recommended Usage：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser：Red Laser (633 nm)
Application Notes：Clone 10.1 recognizes the EC3 epitope of CD64. While both contain the EC3 domain, in-house testing suggests that clone 10.1 preferentially binds to CD64A (FcγRIA), but not CD64B (FcγRIB). Additional reported applications (for the relevant formats) include: blocking of human IgG3 and murine IgG2a binding to FcγRI2,5,6,11 and immunohistochemical staining of acetone-fixed frozen tissue sections12.
Additional Product Notes：BioLegend is in the process of converting the name APC/Cy7 to APC/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our APC/Cyanine7 products. Please contact Technical Service if you have any questions.
Application References：
1.McMichael A, et al. Eds. 1987. Leucocyte Typing III. Oxford University Press. New York.
2.Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. p. 874.
3.Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London.
4.Holl V, et al. 2004. J. Immunol. 173:6274.
5.Hober D, et al. 2002. J. Gen. Virol. 83:2169.
6.Cho HJ, et al. 2007. Physiol Genomics 149:60.
7.van Tits L, et al. 2005. Arterioscler Thromb Vasc Biol. 25:717. PubMed
8.Bruhns P, et al. 2008. Blood 113:3716. PubMed
9.Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
10.Carter DL, et al. 1999. Cytometry 37:41. (FC)
11.Dougherty GJ, et al. 1987. Eur. J. Immunol. 17:1453.
12.Blom AB, et al. 2003. Arthritis Rheum. 48(4):1002-14. (IHC)
Product Citations：
1.Cassetta L et al. 2019. Cancer Cell. 35(4):588-602 . PubMed
2.Santra S, et al. 2015. PLoS Pathog. 11: 1005042. PubMed
3.Quast I, et al. 2015. Neurol Neuroimmunol Neuroinflamm. 2: e148. PubMed
Structure：Ig superfamily, type I glycoprotein, 72 kD
Distribution：Monocytes, macrophages, dendritic cells, activated granulocytes
Function：Phagocytosis, ADCC
Ligand/Receptor：IgG receptor
Cell Type：Dendritic cells, Granulocytes, Macrophages, Monocytes
Biology Area：Immunology, Innate Immunity
Molecular Family：CD Molecules, Fc Receptors
Antigen References：
1. Hulett M, et al. 1994. Adv. Immunol. 57:1.
2. van de Winkel J, et al. 1993. Immunol. Today 14:215.
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APC/Cyanine7 抗人 CD64 抗体
￥2500 - 6100
