BioLegend 351347 APC/Cyanine7

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BioLegend 351347 APC/Cyanine7 anti-human CD127 (IL-7Rα)
产品简介：
产品品牌：BioLegend
产品货号：351347
产品名称：BioLegend 351347 APC/Cyanine7 anti-human CD127 (IL-7Rα)
产品规格：25 tests

产品说明：
Clone   A019D5 (See other available formats)
Regulatory Status  RUO
Other Names   IL-7 receptor α chain, IL-7Rα
Isotype  Mouse IgG1, κ

描述
CD127 是一种 60-90 kD 的 I 型跨膜糖蛋白，也称为 IL-7 受体α链或 IL-7Rα。它与共同的γ链（γc或CD132）形成异二聚体，与IL-2，IL-4，IL-9，IL-13，IL-15和IL-21的受体共享。CD127 通过早期前 B 期细胞、胸腺细胞（CD4/CD8 双阳性胸腺细胞除外）、外周 T 细胞和骨髓基质细胞在未成熟 B 细胞上表达。据报道，CD127是识别记忆和效应T细胞的有用标志物。研究表明，CD127的表达在Treg细胞上是下调的。它可以用作Treg和常规T细胞分化的标志物。IL-7与其受体的连接对于刺激成熟和未成熟的T细胞以及未成熟的B细胞增殖和发育很重要。
CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.

Product Details
Isotype Control   APC/Cyanine7 Mouse IgG1, κ Isotype Ctrl
Verified Reactivity   Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus

Antibody Type   Monoclonal
Host Species   Mouse
Immunogen   Recombinant human CD127
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation
The antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions.

Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application   FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser   Red Laser (633 nm)
Application Notes
Additional reported (for the relevant formats) application: proteogenomics1.

Antigen Details
Structure
Type I transmembrane glycoprotein, associates with CD132, 60-90 kD
Distribution
Immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, bone marrow stromal cells

Function
T cell and immature B cell proliferation and development
Ligand/Receptor   IL-7
Cell Type   B cells, T cells, Thymocytes, Tregs
Biology Area   Immunology

Molecular Family
CD Molecules, Cytokine/Chemokine Receptors

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