产品说明: Clone Bu15 (See other available formats) Regulatory Status RUO Workshop V S143 Other Names Integrin αx subunit, ITGAX, CR4, p150 Isotype Mouse IgG1, κ
描述 CD11c 是一种 145-150 kD I 型跨膜糖蛋白,也称为整合素 αx 和 CR4。CD11c 与整合素 β2 (CD18) 非共价结合,并在单核细胞/巨噬细胞、树突状细胞、粒细胞、NK 细胞以及 T 和 B 细胞亚群上表达。据报道,CD11c 通过与纤维蛋白原、CD54 和 iC3b 的相互作用在粘附和 CTL 杀伤中发挥作用。 CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.
Product Details Isotype Control APC/Cyanine7 Mouse IgG1, κ Isotype Ctrl Verified Reactivity Human Antibody Type Monoclonal Host Species Mouse Formulation Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation The antibody was purified by affinity chromatography, and conjugated with APC/Cyanine7 under optimal conditions.
Concentration Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. Application FC - Quality tested
Recommended Usage Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser Red Laser (633 nm) Application Notes Clone Bu15 has a different binding epitope than clone 3.9. The binding of Bu15 with CD11c is divalent cation independent. Additional reported applications (for the relevant formats of this clone) include: inhibition of CD11c mediated adhesion and stimulation of chemokine production by monocytes.
Additional Product NotesBioLegend is in the process of converting the name APC/Cy7 to APC/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our APC/Cyanine7 products. Please contact Technical Service if you have any questions.
Antigen Details Structure Integrin, type I transmembrane glycoprotein, associates with integrin β2 (CD18), 145-150 kD
Distribution Myeloid, dendritic cells, NK cells, B cells and T cell subsets
Function Adhesion, CTL killing Ligand Receptor: CD54, fibrinogen, iC3b, ICAM-1, ICAM-4 Antigen Cell Type B cells, Dendritic cells, Neutrophils, NK cells, T cells Biology Area Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers Molecular Family Adhesion Molecules, CD Molecules