产品说明: Clone Ber-ACT35 (ACT35) (See other available formats) Regulatory Status RUO Other Names ACT35 antigen, tumor necrosis factor receptor superfamily member 4 (TNFRSF4) Isotype Mouse IgG1, κ
描述 CD134,也称为OX40和TNFRSF4,是一种50 kD I型跨膜糖蛋白。它是TNF受体家族的成员。OX40在活化的T淋巴细胞上表达,包括Th1,Th2,Th17和Treg细胞。OX40与OX40L的相互作用导致B细胞增殖和抗体分泌,调节原代T细胞扩增和T细胞存活。OX40影响T细胞记忆池的大小和CD4 + T细胞耐受性的调节。 CD134, also known as OX40 and TNFRSF4, is a 50 kD type I transmembrane glycoprotein. It is a member of the TNF receptor family. OX40 is expressed on activated T lymphocytes including Th1, Th2, Th17, and Treg cells. The interaction of OX40 with OX40L results in B cell proliferation and antibody secretion, regulation of primary T cell expansion, and T cell survival. OX40 influences the size of the T cell memory pool and regulation of CD4+ T cell tolerance.
Product Details Isotype Control Brilliant Violet 711™ Mouse IgG1, κ Isotype Ctrl Verified Reactivity Human Reported Reactivity Chimpanzee Antibody Type Monoclonal Host Species Mouse Immunogen HTLV 1-transformed HUT 102 cells
Preparation The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 711™ under optimal conditions.
Concentration Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. Application FC - Quality tested
Recommended Usage Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Brilliant Violet 711™ excites at 405 nm and emits at 711 nm. The bandpass filter 710/50 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 711™ is a trademark of Sirigen Group Ltd.
Learn more about Brilliant Violet™.
This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents. Excitation Laser Violet Laser (405 nm)
Application Notes Additional reported applications (for the relevant formats) include: Western blotting1, immunoprecipitation1, immunohistochemical staining2,3of paraffin embedded7 and frozen tissue sections, ELISA4, and functional assay5. The LEAF™ or Ultra-LEAF™ purified antibody is recommended for functional assays (contact our custom solutions team).
Antigen Details Structure 50 kD, TNF receptor family Distribution Activated T cells
Function Receptor for OX40 ligand, co-stimulatory signal for T cell proliferation and survival. Ligand/Receptor OX40L (CD252) Cell Type T cells, Tregs
Biology Area Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Costimulatory Molecules, Immunology
Molecular Family CD Molecules, Immune Checkpoint Receptors