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99
- 英文名：
APC anti-human TCR γ/δ
- 供应商：
北京云肽生物科技有限公司
BioLegend 331211 APC anti-human TCR γ/δ
北京云肽生物科技有限公司作为 BioLegend 的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
美国 BioLegend 公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend 虽然成立的时间不长，但它聚集了一批来自 PharMingen 公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。
BioLegend 公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。
BioLegend 331211 APC anti-human TCR γ/δ
产品简介：
产品品牌：BioLegend
产品货号：331211
产品名称：BioLegend 331211 APC anti-human TCR γ/δ
产品规格：25 tests
产品说明：
Clone B1 (See other available formats)
Regulatory Status RUO
Other Names T cell receptor γ/δ, γ/δ TCR, TCR-γ/δ
Isotype Mouse IgG1, κ
描述
T细胞受体（TCR）是由α和β链（TCR α/β）或γ和δ链（TCR γ/δ）组成的异二聚体。TCR γ/δ 参与识别与 MHC I 类结合的某些细菌、自身 CD1 分子和肿瘤抗原。γ/δ TCR 与 CD3 相关，并在胸腺、肠上皮、外周淋巴组织和腹膜中发现的 T 细胞亚群上表达。大多数γ/δ T细胞是CD4-/CD8-，有些是CD8+。表达 γ/δ TCR 的 T 细胞已被证明在口服耐受、某些肿瘤细胞的先天免疫应答和自身免疫性疾病中发挥作用。据报道，γ/δ T细胞在抗原呈递中也起主要作用。
T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR γ/δ is involved in the recognition of certain bacterial, self-CD1 molecule, and tumor antigens bound to MHC class I. The γ/δ TCR associates with CD3 and is expressed on a subset of T cells found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8-, some are CD8+. T cells expressing the γ/δ TCR have been shown to play a role in oral tolerance, innate immune response for some tumor cells, and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in antigen presentation.
Product Details
Isotype Control APC Mouse IgG1, κ Isotype Ctrl (FC)
Verified Reactivity Human, Cynomolgus, Rhesus
Reported Reactivity African Green, Baboon, Pigtailed Macaque
Antibody Type Monoclonal
Host Species Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & HandlingThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser Red Laser (633 nm)
Application Notes
Clone B1 is also known as clone B1.1.
Additional reported applications (for the relevant formats) include: immunohistochemical staining of *-fixed frozen sections3 and paraffin-embedded sections5, in vitro blocking, and spatial biology (IBEX)8,9. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for highly sensitive assays (Cat. Nos. 331235 and 331236).
Antigen Details
Structure Ig superfamily, associates with CD3 complex
Distribution
T subset in thymus, intestinal epithelium, peripheral lymphoid tissues and peritoneum
Function Antigen recognition
Ligand/Receptor
Some bacterial or tumor antigens bound MHC class I, CD1 molecule
Cell Type Epithelial cells, T cells
Biology Area Adaptive Immunity, Immunology
Molecular Family TCRs
以下是 BioLegend 品牌部分产品，如需其他产品请联系本公司销售。
BioLegend 300541 Purified anti-human CD4 (Maxpar® Ready) RPA-T4 100 ug
BioLegend 300545 Brilliant Violet 510™ anti-human CD4 RPA-T4 25 tests
BioLegend 300550 PE anti-human CD4 RPA-T4 100 ug
BioLegend 300552 APC anti-human CD4 RPA-T4 100 ug
BioLegend 300553 Brilliant Violet 785™ anti-human CD4 RPA-T4 25 tests
BioLegend 300554 Brilliant Violet 785™ anti-human CD4 RPA-T4 100 tests
BioLegend 300556 Brilliant Violet 605™ anti-human CD4 RPA-T4 100 tests
BioLegend 300557 Brilliant Violet 711™ anti-human CD4 RPA-T4 25 tests
BioLegend 300558 Brilliant Violet 711™ anti-human CD4 RPA-T4 100 tests
BioLegend 300559 APC/Fire™ 750 anti-human CD4 RPA-T4 25 tests
BioLegend 300602 Purified anti-human CD5 UCHT2 100 ug
BioLegend 300606 FITC anti-human CD5 UCHT2 100 tests
BioLegend 300607 PE anti-human CD5 UCHT2 25 tests
BioLegend 300608 PE anti-human CD5 UCHT2 100 tests
BioLegend 300611 APC anti-human CD5 UCHT2 25 tests
BioLegend 300612 APC anti-human CD5 UCHT2 100 tests
BioLegend 300618 PerCP anti-human CD5 UCHT2 100 tests
BioLegend 300620 PerCP/Cyanine5.5 anti-human CD5 UCHT2 100 tests
BioLegend 300622 PE/Cyanine7 anti-human CD5 UCHT2 100 tests
BioLegend 300626 Brilliant Violet 421™ anti-human CD5 UCHT2 100 tests
BioLegend 300634 PE/Dazzle™ 594 anti-human CD5 UCHT2 100 tests
BioLegend 300804 PE anti-human CD137 (4-1BB) S18014C 100 tests
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文献和实验相关实验
【进展|热点】Immunity: γδ T细胞抑制调节性T细胞
γδ T细胞抑制调节性T细胞 文章出处：γδ T Cells Enhance Autoimmunity by Restraining Regulatory T Cell Responses via an Interleukin-23-Dependent Mechanism. Immunity. 2010. 33:351-363 主要内容： T细胞根据其TCR链的不同可以分为αβ T细胞和γδ T细胞两类，前者是经典的T细胞，我们常规提到的T细胞指的就是αβ T细胞。γδ
一．γδT简介 γδ T细胞是表面具有独特T细胞受体（TCR）的T细胞。大多数T细胞是αβ T细胞，其TCR由两个糖蛋白链组成，称为α和β TCR链。相比之下，γδ T细胞具有由一个γ 链和一个δ 链组成的TCR。αβT和γδT细胞谱系起源于缺乏CD4和CD8共受体（CD4-CD8-）的T前体细胞，也称为双阴性（DN）胸腺细胞（图1）。γδT细胞通常不如αβ T细胞常见，但在粘膜和上皮部位显着富集，例如皮肤和呼吸道，消化道和生殖道。与αβT细胞相比，γδT细胞是主要的组织相容性复合物（MHC
Cell Surface Immunofluorescence Staining Protocol
. In the mouse, purified anti-mouse CD16/CD32 antibody specific for Fcγ R III/II (BioLegend Cat. #101302, clone 93) can be used to block nonspecific staining of antibodies. In this case, block Fc receptors by pre-incubating cells with 5-10 μg/ml purified anti-CD
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BioLegend 331211 APC anti-human TCR γ/δ
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