BioLegend 331211 APC anti-huma

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BioLegend 331211 APC anti-human TCR γ/δ
产品简介：
产品品牌：BioLegend
产品货号：331211
产品名称：BioLegend 331211 APC anti-human TCR γ/δ
产品规格：25 tests

产品说明：
Clone  B1 (See other available formats)
Regulatory Status  RUO
Other Names  T cell receptor γ/δ, γ/δ TCR, TCR-γ/δ
Isotype  Mouse IgG1, κ

描述
T细胞受体（TCR）是由α和β链（TCR α/β）或γ和δ链（TCR γ/δ）组成的异二聚体。TCR γ/δ 参与识别与 MHC I 类结合的某些细菌、自身 CD1 分子和肿瘤抗原。γ/δ TCR 与 CD3 相关，并在胸腺、肠上皮、外周淋巴组织和腹膜中发现的 T 细胞亚群上表达。大多数γ/δ T细胞是CD4-/CD8-，有些是CD8+。表达 γ/δ TCR 的 T 细胞已被证明在口服耐受、某些肿瘤细胞的先天免疫应答和自身免疫性疾病中发挥作用。据报道，γ/δ T细胞在抗原呈递中也起主要作用。
T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR γ/δ is involved in the recognition of certain bacterial, self-CD1 molecule, and tumor antigens bound to MHC class I. The γ/δ TCR associates with CD3 and is expressed on a subset of T cells found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8-, some are CD8+. T cells expressing the γ/δ TCR have been shown to play a role in oral tolerance, innate immune response for some tumor cells, and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in antigen presentation.

Product Details
Isotype Control   APC Mouse IgG1, κ Isotype Ctrl (FC)
Verified Reactivity   Human, Cynomolgus, Rhesus
Reported Reactivity   African Green, Baboon, Pigtailed Macaque
Antibody Type   Monoclonal
Host Species   Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.

Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & HandlingThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application  FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser  Red Laser (633 nm)
Application Notes  
Clone B1 is also known as clone B1.1.
Additional reported applications (for the relevant formats) include: immunohistochemical staining of *-fixed frozen sections3 and paraffin-embedded sections5, in vitro blocking, and spatial biology (IBEX)8,9. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for highly sensitive assays (Cat. Nos. 331235 and 331236).

Antigen Details
Structure   Ig superfamily, associates with CD3 complex
Distribution
T subset in thymus, intestinal epithelium, peripheral lymphoid tissues and peritoneum

Function  Antigen recognition
Ligand/Receptor
Some bacterial or tumor antigens bound MHC class I, CD1 molecule
Cell Type  Epithelial cells, T cells
Biology Area   Adaptive Immunity, Immunology
Molecular Family   TCRs

以下是 BioLegend 品牌部分产品，如需其他产品请联系本公司销售。
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BioLegend 300553 Brilliant Violet 785™ anti-human CD4     RPA-T4      25 tests
BioLegend 300554 Brilliant Violet 785™ anti-human CD4     RPA-T4      100 tests
BioLegend 300556 Brilliant Violet 605™ anti-human CD4     RPA-T4      100 tests
BioLegend 300557 Brilliant Violet 711™ anti-human CD4     RPA-T4      25 tests
BioLegend 300558 Brilliant Violet 711™ anti-human CD4     RPA-T4      100 tests
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BioLegend 300606 FITC anti-human CD5 UCHT2 100 tests
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BioLegend 300620 PerCP/Cyanine5.5 anti-human CD5  UCHT2 100 tests
BioLegend 300622 PE/Cyanine7 anti-human CD5     UCHT2 100 tests
BioLegend 300626 Brilliant Violet 421™ anti-human CD5     UCHT2 100 tests
BioLegend 300634 PE/Dazzle™ 594 anti-human CD5     UCHT2 100 tests
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