产品说明: Clone C15.6 (See other available formats) Regulatory Status RUO Other Names Interleukin-12 p40, Interleukin-23 p40, Cytotoxic lymphocyte maturation factor (CLMF), Natural killer cell stimulatory factor (NKSF), CTL maturation factor (TcMF), T-cell stimulating factor (TSF) Isotype Rat IgG1, κ
描述 C15.6抗体与IL-12 p70的小鼠IL-12 p40亚基和IL-23 p19/p40的IL-23 p40亚基以及p40单体和同源二聚体或异二聚体反应。C15.6抗体不能中和天然或重组IL-12的生物活性。 The C15.6 antibody reacts with mouse IL-12 p40 subunit of the IL-12 p70 and IL-23 p40 subunit of the IL-23 p19/p40, as well as p40 monomer and homodimer, or heterodimer. The C15.6 antibody can not neutralize the bioactivity of natural or recombinant IL-12.
Product Details Isotype Control PE/Cyanine7 Rat IgG1, κ Isotype Ctrl Verified Reactivity Mouse, IL-12/IL-23 p40 subunit (monomer, homodimer and heterodimer IL-12 p35/p40 or IL-23 p19/p40) Antibody Type Monoclonal Host Species Rat Immunogen CHO-expressed, recombinant mouse IL-12 p70
Preparation The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions. Concentration 0.2 mg/ml Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. Application ICFC - Quality tested
Recommended Usage Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details Structure Cytokine; monomer, heterodimer (p40:p35 or p40:p19) or homodimer (p40:p40)
Bioactivity IL-12 p70 (p40:p35) induces IFN-γ, TNF-a production in T and NK cells; costimulation of PBL proliferation; proliferation/differentiation of TH1 T lymphocytes. IL-23 (p40:p19) induces proliferation and production of IFN-γ by human me
Cell Sources Dendritic cells, monocytes/macrophages, B cells, T cells Cell Targets T cells, NK cells Receptors IL-12Rβ1 binds p40; dimeric with IL-12Rβ2 binds p35 Biology Area Immunology, Innate Immunity Molecular Family Cytokines/Chemokines