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- 英文名：
Alexa Fluor® 594 anti-mouse CD169 (Siglec-1)
- 供应商：
北京云肽生物科技有限公司
BioLegend 142416 Alexa Fluor® 594 anti-mouse CD169 (Siglec-1)
北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
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BioLegend 142416 Alexa Fluor® 594 anti-mouse CD169 (Siglec-1)
产品简介：
产品品牌：BioLegend
产品货号：142416
产品名称：BioLegend 142416 Alexa Fluor® 594 anti-mouse CD169 (Siglec-1)
产品规格：100 µg
产品说明：
Clone 3D6.112 (See other available formats)
Regulatory Status RUO
Other Names
Sialic acid binding Ig-like lectin 1 (Siglec-1), Sialoadhesin (Sn)
Isotype Rat IgG2a, κ
描述
CD169，也称为Siglec-1和Sialoadhesin（Sn），是一种I型凝集素，包含17个免疫球蛋白（Ig）结构域（一个可变结构域和16个恒定结构域）。CD169与唾液酸结合，唾液酸可在PSGL-1、CD43、CD206和CD227上发现。通过与α2，3-连接唾液酸的亲和力，它参与巨噬细胞与不同细胞类型的结合，如粒细胞、单核细胞、NK、B和T细胞。CD169最初被鉴定为小鼠常驻骨髓细胞上的唾液酸依赖性绵羊红细胞受体（SER）。它已被鉴定为在常驻骨髓巨噬细胞上高度表达，巨噬细胞在间充质干细胞生态位中保留干细胞方面发挥着重要作用。在脾脏、淋巴结、骨髓、肝脏、结肠、肺部和癌症细胞中的一些特定的组织巨噬细胞亚群中也发现了它。有证据表明，CD169阳性巨噬细胞作为淋巴结驻留APC，主导肿瘤抗原特异性CD8+T细胞和不变NK细胞的早期激活。
CD169, also known as Siglec-1 and Sialoadhesin (Sn), is a type I lectin containing 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains). CD169 binds to sialic acids, which can be found on PSGL-1, CD43, CD206, and CD227. By its affinity to α2, 3-linked sialic acid, it is involved in macrophage binding to different cell types such as granulocytes, monocytes, NK, B, and T cells. CD169 was initially identified as a sialic acid-dependent sheep erythrocyte receptor (SER) on resident bone marrow cells of mice. It has been identified as highly expressed on resident bone marrow macrophages which plays an important role in retention of stem cells in mesenchymal stem cell niche. It is also found on some specific subsets of tissue macrophages in spleen, lymph nodes, bone marrow, liver, colon, lungs, and cancer cells. Evidence suggest that CD169-positive macrophages serve as lymph node-resident APCs to dominate early activation of tumor antigen-specific CD8+ T cells and invariant NK cell.
Product Details
Isotype Control Alexa Fluor® 594 Rat IgG2a, κ IsotypeCtrl
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Rat
Immunogen Purified Native Sialoadhesin from spleen
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions.
Concentration 0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application IHC-F - Quality tested
3D IHC - Verified
Recommended Usage
Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a concentration range of 2.5 - 10 µg/ml is suggested. For 3D immunohistochemistry on formalin-fixed tissues, a concentration of 5.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
View full statement regarding label licenses
Application Notes
Additional reported applications (for the relevant formats) include: immunohistochemical staining in frozen tissue sections1, and spatial biology (IBEX)4,5.
Antigen Details
Structure
Type I single membrane-spanning lectin containing 17 immunoglobulin (Ig) domains, belongs to the immunoglobulin superfamily.
Distribution
Macrophages in spleen, lymph nodes, bone marrow, liver, colon and lungs.
Function Adhesion.
Ligand/Receptor PSGL-1, CD43, CD206 and CD227.
Cell Type Macrophages
Biology Area Cell Biology, Immunology
Molecular Family
Adhesion Molecules, CD Molecules, Protein Kinases/Phosphatase, Siglec Molecules
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BioLegend 142416 Alexa Fluor® 594 anti-mouse CD169 (Siglec-1)
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