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99
- 英文名：
PE/Cyanine7 anti-mouse/human KLRG1 (MAFA)
- 供应商：
北京云肽生物科技有限公司
BioLegend 138416 PE/Cyanine7 anti-mouse/human KLRG1 (MAFA)
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BioLegend 138416 PE/Cyanine7 anti-mouse/human KLRG1 (MAFA)
产品简介：
产品品牌：BioLegend
产品货号：138416
产品名称：BioLegend 138416 PE/Cyanine7 anti-mouse/human KLRG1 (MAFA)
产品规格：100 µg
产品说明
Clone 2F1/KLRG1 (See other available formats)
Regulatory Status RUO
Other Names MAFA, 2F1-Ag
Isotype Syrian Hamster IgG
描述
杀伤细胞凝集素样受体G1（KLRG1）是大鼠肥大细胞功能相关抗原（MAFA或2F1-Ag）的小鼠同源物。KLRG1是一种II型膜糖蛋白，首次在大鼠肥大细胞系RBL-2H3的表面鉴定。它由糖基化的30-38kD亚基的同源二聚体组成。KLRG1的小鼠和人同源物由NK细胞和淋巴因子激活的杀伤细胞（LAK）亚群表达，但不由肥大细胞表达。KLRG1也在CD8+和CD4+细胞的亚群上表达，包括CD4+和CD8+效应/记忆细胞，有效的调节性CD4+T细胞。KLRG1可能参与调节NK细胞稳态。发现KLRG1识别钙粘蛋白，从而通过调节效应器功能和NK细胞和T细胞的发育过程来抑制免疫反应。
Killer cell lectin-like receptor G1 (KLRG1) is the mouse homolog of the rat mast cell function-associated antigen (MAFA or 2F1-Ag). KLRG1 is a type II membrane glycoprotein that was first identified on the surface of rat mast cell line RBL-2H3. It is composed of a homodimer of glycosylated 30-38 kD subunits. Mouse and human homologs of KLRG1 are expressed by subsets of NK cells and lymphokine-activated killer (LAK) cells but not mast cells. KLRG1 is also expressed on subsets of CD8+ and CD4+ cells, including CD4+ and CD8+ effector/memory cells, potent regulatory CD4+ T cells. KLRG1 may be involved in regulating NK cell homeostasis. KLRG1 was found to recognize cadherins and thus inhibit immune responses by regulating the effector function and the developmental processes of NK and T cells.
Product Details
Verified Reactivity Mouse, Human
Antibody Type Monoclonal
Host Species Syrian Hamster
Immunogen IL-2 activated NK cells from C57BL/6 mice
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
Concentration 0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is =0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes
For successful staining of human cells, brighter fluorophore-antibody conjugates, such as PE, BV421™, or APC, are recommended.
Additional reported applications (for relevant formats) include: Western Blotting1.
Additional Product Notes
BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
Antigen Details
Structure
KLRG1 is an inhibitory lectin-like type II transmembrane receptor containing a cytoplasmic motif similar to ITIM, expressed mainly as a homodimeric molecule consisting of two N-glycosylated subunits of approximately 30-38 kD.
Distribution
Subsets of NK cells, lymphokine-activated killer (LAK) cells and subsets of CD8 and CD4 cells.++
Function
Regulates NK cell proliferation, maturation, and homeostasis. Inhibits immune responses by regulating the effector function and the developmental processes of NK and T cells.
Ligand/Receptor E-cadherin
Cell Type NK cells, T cells, Tregs
Biology Area Immunology, Innate Immunity
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文献和实验相关实验
Cell Surface Immunofluorescence Staining Protocol
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) RPMI 1640 medium without phenol red Primary antibodies: Lyve‐1, unconjugated (R&D) and PE‐conjugated CD31 (BioLegend
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BioLegend 138416 PE/Cyanine7 anti-mouse/human KLRG1 (MAFA)
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