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99
- 英文名：
Purified anti-mouse CD194 (CCR4)
- 供应商：
北京云肽生物科技有限公司
BioLegend 131202 Purified anti-mouse CD194 (CCR4)
北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。
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BioLegend 131202 Purified anti-mouse CD194 (CCR4)
产品简介：
产品品牌：BioLegend
产品货号：131202
产品名称：BioLegend 131202 Purified anti-mouse CD194 (CCR4)
产品规格：100 µg
产品说明：
Clone 2G12 (See other available formats)
Regulatory Status RUO
Other Names CC CKR-4, CHEMR1, Cmkbr4, LESTR, MGC151418, Sdf1r
Isotype Armenian Hamster IgG
描述
小鼠CCR4 cDNA含有1531bp，编码一种360个氨基酸的蛋白质，与人CCR4的同源性为85%。CCR4结合CCL17（TARG）和CCL22（MDC）。携带皮肤抗原受体的幼稚T细胞在皮肤引流淋巴结中被激活，并表达皮肤淋巴细胞抗原（CLA），这赋予这些细胞迁移到皮肤中以发挥其正常效应器功能的能力（1）。CCR4和CCR10在配体介导的T细胞向小鼠和人类皮肤的募集中发挥着重要作用，特别是在束缚、牢固粘附和随后外渗到损伤部位方面（2，3）。CCR4在皮肤调节性T细胞（Tregs）中表达。这些细胞对诱导和维持自身耐受至关重要，在正常、无炎症条件下存在于皮肤和肠道等外周组织中（4）。此外，介导同种异体移植耐受的Foxp3+T调节细胞的募集依赖于CCR4趋化因子受体及其配体CCL22（5）。
Mouse CCR4 cDNA contains 1531 bp, and encodes a protein of 360 amino acids that is 85% identical to human CCR4. CCR4 binds CCL17 (TARG) and CCL22 (MDC). Naïve T cells, bearing receptors for cutaneous antigens, become activated in skin-draining lymph nodes and express cutaneous lymphocyte antigen (CLA), which confers to these cells the capacity to migrate into the skin to exert their normal effector functions (1). CCR4 and CCR10 play an important role in the ligand-mediated recruitment of T cells into the skin in mice and humans, specifically with regards to tethering, firm adhesion, and subsequent extravasation to the site of injury (2,3). CCR4 is expressed in cutaneous regulatory T cells (Tregs). These cells are crucial for the induction and maintenance of self-tolerance and are present in peripheral tissues such as skin and gut under normal, noninflamed conditions (4).In addition, recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor and its ligand CCL22 (5).
Product Details
Isotype Control Purified Armenian Hamster IgG Isotype Ctrl
Verified Reactivity Mouse
Antibody Type Monoclonal
Host Species Armenian Hamster
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation The antibody was purified by affinity chromatography.
Concentration 0.5 mg/ml
Storage & Handling The antibody solution should be stored undiluted between 2°C and 8°C.
Application FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details
Structure GPCR, chemokine receptor, seven transmembrane receptor
Distribution
Memory T cells, macrophages, platelets, basophils, Th2 cells, and Tregs
Function
CCR4 and its ligands (CCL17 and CCL22) are important for the recruitment of memory T cells into the skin in various cutaneous immune diseases.
Interaction
Interaction between CCR4 and its ligand TARC/CCL17 on activated endothelial cells mediates T cell extravasation by stimulating integrin-dependent adhesion
Ligand/Receptor CCl17 and CCL22
Cell Type Basophils, Embryonic Stem Cells, Macrophages, Platelets, T cells, Th2, Tregs
Biology Area Immunology, Stem Cells
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
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BioLegend 131202 Purified anti-mouse CD194 (CCR4)
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