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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
Interleukin-2
- 抗体英文名：
Interleukin-2
- 靶点：
-
- 浓度：
>95% by SDS-PAGE
- 应用范围：
-
- 宿主：
Human
- 适应物种：
-
- 保质期：
Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
- 抗原来源：
-
- 目录编号：
-
- 级别：
-
- 库存：
现货
- 供应商：
爱必信(上海)生物科技有限公司
- 标记物：
-
- 克隆性：
-
- 保存条件：
Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.
- 形态：
Lyophilized Powder
- 亚型：
-
- 免疫原：
-
- 规格：
10ug/50ug/100ug/500ug
| 规格： | 10ug | 产品价格： | ￥500.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥900.0 |
| 规格： | 100ug | 产品价格： | ￥1200.0 |
| 规格： | 500ug | 产品价格： | ￥4320.0 |
| 概述 | |
| 别名 | Interleukin-2 |
| 种属 | Human |
| 来源 | E.coli |
| 分子量 | 15.5 kDa |
| 外观 | Lyophilized Powder |
| 形态 | Lyophilized from 20mM PB, 150mM NaCl, 5% Trehalose, pH 7.4 |
| 性能 | |
| 序列 | Ala21-Thr153 |
| 标签 | No Tag |
| 纯度 | >95% by SDS-PAGE |
| 内毒素水平 | <0.1EU/ug |
| 溶解方法 | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| 储存/保存方法 | Within 1 week, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles. |
| 靶标 | |
| 背景说明 | Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotropic hormone that is instrumental in the body natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit cross-species activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (T-Regs). After exiting from the thymus, T-Regs function to prevent other T cells from recognizing and reacting against "self-antigens", which could result in "autoimmunity". T-Regs do this by preventing the responding cells from producing IL-2. Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system. |
| Accession | P60568 |
| 参考文献 | |
| 参考文献 | 1.Pol, J. G. , Caudana, P. , Paillet, J. , Piaggio, E. , & Kroemer, G. . (2020). Effects of interleukin-2 in immunostimulation and immunosuppression. The Journal of Experimental Medicine(1), 217.2.Kolios, A. G., Tsokos, G. C., & Klatzmann, D. (2021). Interleukin-2 and regulatory T cells in rheumatic diseases. Nature Reviews Rheumatology, 17(12), 749-766.3.Zhang, Y., & Su, J. (2023). Interleukin-2 family cytokines: An overview of genes, expression, signaling and functional roles in teleost. Developmental & Comparative Immunology, 104645. |
实验结果图：
Anti-His antibody Immobilized on CM5 Chip captured IL-2R alpha/CD25 His Tag, Human (Cat. No. UA010367), can bind IL-2, Human (Cat. No. UA040108) with an affinity constant of 13.94 nM as determined in SPR assay.
Anti-His antibody Immobilized on CM5 Chip captured IL-2R alpha/CD25 His Tag, Mouse (Cat. No. UA010324), can bind IL-2, Human (Cat. No. UA040108) with an affinity constant of 20.57 nM as determined in SPR assay.
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技术资料