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- 2025年12月05日
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mTOR inhibitor-11
MCE 国际站：mTOR inhibitor-11
产品活性：mTOR inhibitor-11 (Compound 9) 是一种可穿透大脑屏障的 mTOR抑制剂(IC50: 对 pS6 为21 nM)。mTOR inhibitor-11 还抑制 pCHK1 和 PDE4D，IC50分别为17.2和17.0 μM。mTOR inhibitor-11 可用于中枢神经系统疾病研究。
研究领域：PI3K/Akt/mTOR
作用靶点：mTOR
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文献和实验Molecular Detection of t(11;14)(q13;q32) in Mantle Cell Lymphoma
Mantle cell lymphoma (MCL) is characterized by the presence of t(11;14)(q13;q32) which juxtaposes CCND-1 gene (also known as BCL-1 , PRAD-1 ) at 11q13 with an enhancer of the IGH@ gene at 14q32. The resultant overexpression of cyclin D1 plays
The senescence program is activated in response to diverse stress stimuli potentially compromising genetic stability and leads to an irreversible cell cycle arrest. The mTOR pathway plays a crucial role in the regulation of cell metabolism
The adaptive response to hypoxia, low oxygen tension, involves inhibition of energy-intensive cellular processes including protein translation. This effect is mediated in part through a decrease in the kinase activity of mammalian target
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