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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃.
- 保质期:
Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
- 英文名:
Recombinant Mouse Myelin-oligodendrocyte glycoprotein (Mog), partial
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 规格:
20μg
英文名称:
Recombinant Mouse Myelin-oligodendrocyte glycoprotein (Mog), partial品名简称:
Recombinant Mouse Mog protein, partial货号:
CSB-EP726763MO3规格:
20μg价格:
2328LC-MS/Western Blot:
/SDS-PAGE:
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.纯度:
Greater than 85% as determined by SDS-PAGE.内毒素:
Not test生物活性:
/基因名:
MogUniprot No.:
Q61885别名:
/种属:
Mus musculus (Mouse)蛋白长度:
Partial来源:
E.coli分子量:
20.6 kDa表达区域:
29-156aa氨基酸序列:
GQFRVIGPGYPIRALVGDEAELPCRISPGKNATGMEVGWYRSPFSRVVHLYRNGKDQDAEQAPEYRGRTELLKETISEGKVTLRIQNVRFSDEGGYTCFFRDHSYQEEAAMELKVEDPFYWVNPGVLT蛋白标签:
N-terminal 6xHis-tagged产品提供形式:
Liquid or Lyophilized powder缓冲液:
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.储存条件:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.保质期:
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.货期:
13-23 business days注意事项:
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.功能1:
Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.功能2:
/文献:
"The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis." Clements C.S., Reid H.H., Beddoe T., Tynan F.E., Perugini M.A., Johns T.G., Bernard C.C., Rossjohn J. Proc. Natl. Acad. Sci. U.S.A. 100:11059-11064(2003)研究领域:
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文献和实验开辟先河!STM 背靠背报道非特异性靶点组合 CAR-T 疗法,抗癌效果更好,也更持久
的 synNotch CAR-T 细胞可以将危险副作用的风险最小化,并解决传统 CAR-T 细胞免疫治疗在临床中对实体肿瘤的不良表现。首先,为了解决传统 CAR-T 细胞免疫治疗胶质母细胞瘤的瓶颈,Joseph H. Choe 和他的同事为 synNotch-CAR-T 细胞设计了新的「启动 - 关闭」分子回路,该回路整合了多种「不完美」肿瘤抗原的受体,包括胶质母细胞瘤细胞上的 EGFRvIII 受体或组织特异性蛋白 MOG 等,只有当所有的抗原都存在时,受体才启动并激活 CAR-T 细胞,这也就意味着这种
. Moreover, we report in detail the protocol to administer EPO to mice with myelin oligodendrocyte glycoprotein (MOG)-induced chronic progressive EAE, and a representative result. In this model, EPO inihibits the clinical score of the disease
(glycoprotein),并被传递到致密髓鞘(compact myelin),这些蛋白可能抑制了轴突的再生。缺少这种糖蛋白的小鼠表现出异常的神经节形成(node formation),而且结点处会有新的轴突生成(nodal axon sprouting)。克服这些细胞对轴突生成的抑制作用在神经损伤后的修复治疗有重要临床意义。 图:OMgp缺失的小鼠呈现出异常的中枢神经系统结点和侧索生芽 (OMgp-null mouse exhibits abnormal CNS
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