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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
- 保质期:
Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
- 英文名:
Recombinant Human C-C chemokine receptor type 4 (CCR4)-VLPs (Active)
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 规格:
1mg/100μg/20μg
| 规格: | 1mg | 产品价格: | ¥36252.0 |
|---|---|---|---|
| 规格: | 100μg | 产品价格: | ¥6840.0 |
| 规格: | 20μg | 产品价格: | ¥3420.0 |
纯度:
The purity information is not available for VLPs proteins.基因名:
CCR4Uniprot No.:
P51679别名:
K5-5 CD_antigen: CD194种属:
Homo sapiens (Human)蛋白长度:
Full Length来源:
Mammalian cell分子量:
43.2 kDa表达区域:
1-360aa氨基酸序列:
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL蛋白标签:
C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)产品提供形式:
Lyophilized powder缓冲液:
Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4货期:
3-7 business days注意事项:
The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex.Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).功能:
/内毒素:
Less than 1.0 EU/ug as determined by LAL method.SDS-PAGE:
CSB-MP004843HU is detected by Mouse anti-6*His monoclonal antibody.LC-MS Image Description/Western Blot:
The presence of VLP-like structures was confirmed by TEMProduct types:
MP-VLP Transmembrane Protein & Active Protein & In Stock ProteinBiological_Activity:
①Measured by its binding ability in a functional ELISA. Immobilized Human CCR4 at 10 μg/mL can bind Anti-CCR4 recombinant antibody(CSB-RA004843MA01HU), the EC50 is 362.3-630.8 ng/mL.Research Areas:
CancerReconstitution:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.Reference:
/Function:
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文献和实验Characterization of Chemokine Receptors
Power, C.A., Meyer, A., Nemeth, K., Bacon, K.B., Hoogewerf, A.K., Proudfoot, A.E.I., and Wells, T.N.C. 1995. Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. J. Biol. Chem. 270:19495
Overview of Receptor Allosterism
), a potent, orally bioavailable, and selective small‐molecule inhibitor of chemokine receptor CCR5 with broad‐spectrum anti‐human immunodeficiency virus type 1 activity. Antimicrob. Agents Chemother. 49:4721‐4732.
production of IL-5. Endothelial cells and activated fibroblasts produce IL-33, thus further amplifying local inflammatory responses. Abbreviations: CCL, CC-chemokine ligand; IL, interleukin; TGF, transforming growth factor; TH2 cell, type 2 T helper cell
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