P-CAB agent 2,1978371-23-1

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P-CAB agent 2

CAS No. : 1978371-23-1

MCE 国际站：P-CAB agent 2

产品活性：P-CAB agent 2 是一种有效的且具有口服活性的钾竞争性酸 (potassium-competitive acid) 阻滞剂和胃酸分泌抑制剂。P-CAB agent 2 抑制 H⁺/K⁺-ATPase 活性，IC₅₀ 值为 <100 nM。P-CAB agent 2 抑制 hERG 钾通道，IC₅₀ 值为 18.69 M。P-CAB agent 2 无急性毒性并抑制组胺 (HY-B1204) -诱导的胃酸分泌。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Potassium Channel

In Vitro: P-CAB agent 2 (100 µM) inhibits the hERG potassium channel with an inhibition rate of 86.21% and an IC₅₀ value of 18.69 M.

In Vivo: P-CAB agent 2 (example 1) inhibits histamine (HY-B1204)-induced gastric acid secretion in SD rats.
P-CAB agent 2 (600, 2000 mg/kg; p.o.; once) shows no acute toxicity and 600mg/kg shows no significant effect on animal body weight in SD rats.

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