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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
698346-43-9
- 规格:
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格: | 10 mM * 1 mL | 产品价格: | ¥1250.0 |
|---|---|---|---|
| 规格: | 1 mg | 产品价格: | ¥545.0 |
| 规格: | 5 mg | 产品价格: | ¥1200.0 |
| 规格: | 10 mg | 产品价格: | ¥2000.0 |
| 规格: | 25 mg | 产品价格: | ¥3900.0 |
| 规格: | 50 mg | 产品价格: | ¥6000.0 |
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84-B10
CAS No. : 698346-43-9
MCE 国际站:84-B10
产品活性:84-B10 是一种 3-苯基戊二酸衍生物。84-B10 抑制 cisplatin (HY-17394) 诱导的肾小管铁死亡。84-B10 减轻 cisplatin 诱导的线粒体损伤和氧化应激。84-B10 改善 cisplatin 诱导的急性肾损伤 (AKI)。
研究领域:Apoptosis
作用靶点:Ferroptosis
In Vitro: 84-B10 (10-100 μM; 2 h) inhibits cisplatin-induced tubular epithelial cell ferroptosis in a dose-dependent manner.
84-B10 (40 μM; 2 h; TKPT cells) restores cisplatin-induced mitochondrial structural damage and dysfunction.
84-B10 (40 μM; 2 h; TKPT cells) attenuates mtROS-induced oxidative stress in cisplatin-induced AKI.
84-B10 (40 μM; 2 h; TKPT cells) attenuates cisplatin-induced epithelial cell injury by eliminating mtROS and restoring mitochondrial homeostasis.
In Vivo: 84-B10 (5-15 mg/kg; i.p.) alleviates cisplatin-induced acute kidney injury in mice.
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文献和实验.1 14.9 14.7 14.6 14.5 14.5 14.4 14.3 14.2 14.2 14.1 14.0 13.9 3 4 10.6 9.98 9.60 9.36 9.20 9.07 8.98 8.90 8.84 8.75 8.66 8.56 8.46 8.36 8.26 4 5 8.43 7.76 7.39 7.16 6.98 6.85 6.76 6.68 6.62 6.52 6.43 6.33 6.23 6.12 6.01 5 6 7.26 6.60 5.23
Crystallization of Kinesin Family Motor Proteins
.12 Å2.0 ÅMolecular replacementMotor bound to AMPPCPKIF1A-AMPPCP(co-crystalized)PDB: 1IA0P212121a=42.42 Åb=55.43 Åc=157.27 Å1.9 ÅMolecular replacementMotor bound to AMPPCPNkin 1-355PDB: 1GOJP212121a=51.97 Åb=72.73 Åc=84.93 Å2.3 ÅMolecular replacement
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