重组人B7-H3蛋白

重组人B7-H3蛋白相关信息：

产品分类
重组蛋白
英文名称
Recombinant human B7-H3 protein, C-His (HEK293)
中文名称
重组人B7-H3蛋白
英文别名
B7H3; 4Ig B7 H3; 4Ig-B7-H3; AU016588; B7 H3; B7 homolog 3; B7H3; B7RP-2; CD_antigen=CD276; CD276 antigen; CD276; Costimulatory molecule; PSEC0249; UNQ309/PRO352; CD276_HUMAN; Recombinant human B7-H3 protein, C-His (HEK293)
蛋白细胞定位
细胞膜
分子量
54
浓度
＞0.5 mg/ml
储存液
Lyophilized from 0.22 um filtered solution in PBS (pH=7.4) with 5 mM DTT. Normally 5% trehalose is added as protectant before Lyophilization.
保存条件
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.

重组人B7-H3蛋白

背景资料：The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
研究人员检测CD276在癌症患者来源的内皮细胞中的表达情况，在结肠癌、肺癌、乳腺癌、食道癌和膀胱癌的肿瘤相关血管细胞中发现CD276过量表达，而且这些蛋白在肿瘤细胞本身也过量表达。

重组人B7-H3蛋白应用：仅供研究使用，不用于临床诊断！




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