- ￥3681
- SIGMA
- 美国
- I6909-500UG
- 2025年07月14日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
−20°C
- 保质期：
/
- 英文名：
SIGMA
- 库存：
999
- 供应商：
麦格生物
- 规格：
500UG
说明
免疫原
purified, E. coli-derived recombinant human interleukin-2.
生化/生理作用
Interleukin-2 (IL-2) is a cytokine produced by activated T cells in response to antigen stimulation. IL-2 is important for proliferation of lymphocytes, natural killer cells and macrophages and in the differentiation of CD4+ cells into Th1 and Th2 effector cells. The effects of IL-2 are mediated by the signaling activated by its binding to IL-2 receptor (IL-2 R). IL-2 activates key signaling pathways such as MAPK, JAK/STAT as well as PI3K/Akt. Activation of these pathways modulates production of inflammatory cytokines, survival and progression through cell cycle.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
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文献和实验IL-2 induces a competitive survival advantage in T lymphocytes.
Hans Dooms et al.
Journal of immunology (Baltimore, Md. : 1950), 172(10), 5973-5979 (2004-05-07)
Tumor reactive monoclonal antibodies (mAb) have been developed and tested as anti-tumor therapy. Some mAb have shown efficacy and are now approved as clinical cancer therapy. The mechanism of action for the antitumor effect includes tumor
Monoclonal Antibody Production
and screening of the hybridomas: 1. Bleeding Mice (1) Place the mouse in a mouse restrainer. (2) Sterilize the tail with 70% ethanol. (3) With a razor blade,nip off the last 2 mm of the tip of the tail. (4) Using a milking motion,pull blood down and let
Murine Monoclonal Antibody Development
Major advances in the analysis of biomolecular structure have emerged from the development of highly specific monoclonal antibodies (MAb) by K�hler and Milstein in 1975 (1 ). MAb are produced from hybridoma cell lines that secrete a single
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