泊沙康唑*SIGMA*P-103-1mL

说明

一般描述

经认证的Snap-N-Spike®溶液，适用于通过LC-MS/MS或HPLC在患者血液、血清或血浆样品的泊沙康唑治疗药物监测或临床和诊断测试应用中作为校准品、对照品或线性标准品的起始材料。泊沙康唑以商品名Noxafil®和Posanol出售，是一种三唑类抗真菌药，用于治疗严重免疫功能低下患者的侵袭性真菌感染。

应用

Pharmacokinetic modeling in pediatric patients: Posaconazole intravenous solution and oral powder suspension formulations are studied for their pharmacokinetics in pediatric patients with neutropenia, highlighting the solution′s role in optimizing dosing regimens (Winchell et al., 2024).

Enhanced solubility and bioavailability: Posaconazole antifungal solution is utilized in the development of amorphous solid dispersions with poly(vinylpyridine-co-vinylpyridine N-oxide) excipients, which mediate rapid dissolution and sustained supersaturation, improving its therapeutic efficacy (Liu et al., 2024).

Nanoformulation for oral delivery: A posaconazole-loaded phospholipid-based nanoformulation developed through design of experiments, machine learning, and TOPSIS optimizes oral delivery, enhancing the antifungal′s absorption and therapeutic profile (Bayat et al., 2024).

Cost-utility analysis in fungal prophylaxis: Research on posaconazole solution′s cost-effectiveness in preventing invasive fungal infections among leukemia patients undergoing chemotherapy underscores its potential economic benefits in healthcare settings (Pungprasert et al., 2024).

Cerebrospinal fluid concentrations: Studies assessing the concentrations of posaconazole in cerebrospinal fluid of pediatric leukemia patients validate the solution′s penetration and potential effectiveness in treating central nervous system infections (Körholz et al., 2024).

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