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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件:
瓶身
- 保质期:
coa
- 英文名:
Ganglioside GT1b trisodium salt
- 库存:
999
- 供应商:
麦格生物
- CAS号:
59247-13-1
- 规格:
G3767-5mg
说明
Amino Acid Sequence
Cer-Glc-Gal(NeuAc-NeuAc)-GalNAc-Gal-NeuAc
一般描述
Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum. They contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage. For classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.
应用
Trisialoganglioside-GT1b from bovine brain has been used:
in high performance thin layer chromatography (HPTLC)
in membrane GM1 assays
as reference standards for TLC (thin layer chromatography) and as antigens for ELISA (enzyme-linked immunosorbent assay)
生化/生理作用
Ganglioside marker for metastatic brain tumors. Modulates cellular differentiation; prevents glutamate neurotoxicity; inhibits mitogenesis stimulated by lectins such as Con A. Converted to GD1b by bacterial and mammalian sialidases.
分析说明
Homogeneous aqueous preparations can be obtained by suspending the compound in water, buffer or cell culture medium and sonicating briefly to facilitate the micelle formation.

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- 作者
- 内容
- 询问日期
文献和实验Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly.
Shihu Sun et al.
Cell host & microbe, 10(3), 237-247 (2011-09-20)
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