- ￥3455
- SIGMA
- 美国
- 700042P-1mg
- 2025年07月13日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
瓶身
- 保质期：
coa
- 英文名：
4b-Hydroxy Cholesterol-d7
- 库存：
999
- 供应商：
麦格生物
- CAS号：
1246302-80-6
- 规格：
700042P-1mg
说明
一般描述
4β-hydroxycholesterol (4β-HC) is a catabolic product of cholesterol metabolism mediated by the enzyme cytochrome P450 family 3 subfamily A member 4 (CYP3A4).[1] 4β-hydroxycholesterol-d7 is the deuterated form of 4β-hydroxycholesterol.
应用
4β-hydroxycholesterol-d7 has been used:
as an internal standard to spike plasma samples ultra-high-pressure liquid,chromatography–tandem mass spectrometry (UHPLC-MS/MS) analysis
to spike serum samples for mass spectrometry measurements
as an internal standard for the quantification of human colon biopsies samples using HPLC-MS
生化/生理作用
4β-hydroxycholesterol (4β-HC) may function as a liver X receptor ligand.The levels of 4β-HC are elevated in dextran sulfate induced colitis along with other oxysterols and it may promote colon inflammation.
包装
5 mL Amber Glass Screw Cap Vial (700042P-1mg)
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文献和实验Colitis Alters Oxysterol Metabolism and is Affected by 4β-Hydroxycholesterol Administration.
Owein Guillemot-Legris et al.
Journal of Crohn's & colitis, 13(2), 218-229 (2018-10-09)
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