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- 详细信息
- 技术资料
- 亚型:
IgG
- 形态:
液体
- 保存条件:
-20℃
- 克隆性:
多克隆
- 标记物:
无
- 适应物种:
HMR
- 保质期:
一年
- 抗原来源:
兔
- 供应商:
万类生物
- 宿主:
兔
- 应用范围:
WB、IHC
- 浓度:
>1 mg/ml
- 靶点:
P21/WAF1
- 抗体英文名:
P21/WAF1 antibody
- 抗体名:
P21/WAF1 抗体
- 规格:
50μl(>50μg)
产品概述
The tumor suppressor protein p21 Waf1/Cip1 acts as an inhibitor of cell cycle progression. p21 is a potent, tight-binding inhibitor of Cdks and can inhibit the phosphorylation of Rb by cyclin A-Cdk 2, cyclin E-Cdk2, cyclin D1-Cdk4 and cyclin D2-Cdk4 complexes.The carboxy-terminal region of p21 is sufficient to bind and inhibit PCNA, a subunit of DNA polymerase, and may coordinate DNA replication with cell cycle progression. Upon UV damage or during cell cycle stages when cdc2/cyclin B or CDK2/cyclin A are active, p53 is phosphorylated and upregulates p21 transcription via a p53-responsive element . Protein levels of p21 are downregulated through ubiquitination and proteasomal degradation.
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