GRP78 多克隆抗体

Western Blot（WB）已验证样本:Hela,Jurkat,MCF-7,Mouse lung,Mouse liver,Rat lung,Rat liver,Rat small intestine

WB: 1:500-1000

Polyclonal

IgG

Recombinant Human GRP78 protein expressed by E.coli.

GRP78

BiP; GRP-78; HSP70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding protein; HSPA5抗体

P11021

72kDa

78kDa

Cytoplasm,Endoplasmicreticulumlumen,Cytoplasm,Cellsurface

1.5mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.02% sodium azide, 50% glycerol,pH 7.4

Antigen Affinity Purification

Cancer; Tags and Cell Markers

Unconjugated

GRP78 (Glucose-regulated protein 78 kDa; also BiP and HSPA5) is a 72 kDa member of the heat shock protein 70 family of proteins. Intracellularly, GRP78 is an endoplasmic reticulum chaperone that participates in protein folding; extracellularly, it induces IL-10 production from T cells and interacts with Cripto to block TGF-beta signaling. Human GRP78 precursor is 654 amino acids (aa) in length. It contains an 18 aa signal sequence and a 636 aa mature region that shows a hydantoinase A region (aa 145245) and a C-terminal KDEL motif that is present on intracellular GRP78, but absent on secreted GRP78. There is alternative splicing in the signal sequence (aa 110), and multiple single aa substitituion. Over aa 1654, human GRP78 is more than 97% aa identical to mouse and rat GRP78.